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Cited by 14 publications
(8 citation statements)
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References 57 publications
(63 reference statements)
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“…Depolarization of the mitochondrial membrane potential (ΔΨ m ) is thought to be a critical step in the initiation of apoptotic signaling [ 29 ]. We first used the JC-1 dye to detect ΔΨ m to investigate whether MPA promotes oxidative stress by damaging the mitochondria.…”
Section: Discussionmentioning
confidence: 99%
“…Depolarization of the mitochondrial membrane potential (ΔΨ m ) is thought to be a critical step in the initiation of apoptotic signaling [ 29 ]. We first used the JC-1 dye to detect ΔΨ m to investigate whether MPA promotes oxidative stress by damaging the mitochondria.…”
Section: Discussionmentioning
confidence: 99%
“…Endothelial cells (ECs) line the intimal layer of blood vessels and play an important role in maintaining vascular homeostasis. Ischemic-related oxidative stress-induced dysfunction of ECs and cell death are considered to be the initiating events during IR injury ( Kurian et al, 2016 ; Amruta and Bix, 2021 ; He et al, 2021 ). Thus, rescuing of ECs from IR damage emerges as a potential therapeutic strategy for ischemic diseases such as myocardial infarction, ischemic stroke, and organ transplantation ( Amruta and Bix, 2021 ; Li et al, 2022 ).…”
Section: Introductionmentioning
confidence: 99%
“…Ischemic-related oxidative stress-induced dysfunction of ECs and cell death are considered to be the initiating events during IR injury ( Kurian et al, 2016 ; Amruta and Bix, 2021 ; He et al, 2021 ). Thus, rescuing of ECs from IR damage emerges as a potential therapeutic strategy for ischemic diseases such as myocardial infarction, ischemic stroke, and organ transplantation ( Amruta and Bix, 2021 ; Li et al, 2022 ). Multiple cell death pathways are involved in the pathogenesis of endothelial dysfunction, including apoptosis, autophagy, necroptosis, ferroptosis, and pyroptosis ( Tuo et al, 2022 ).…”
Section: Introductionmentioning
confidence: 99%
“…The BBB is composed of endothelial cells, astrocytic end feet, pericytes and basement membranes, which together modulate the entry of substances or cells circulating in the blood into the brain to maintain a steady environment for normal brain function [ 7 , 8 ]. Structurally, tight junctions (TJs), composed of transmembrane proteins, including zonula occludens (ZOs), claudins and occludin, between brain endothelial cells play a crucial role in maintaining the integrity of the BBB [ 9 , 10 ]. I/R injury usually leads to mitochondrial dysfunction, oxidative stress, inflammatory responses and apoptosis, with a disruption of TJ integrity, resulting in BBB leakage and brain damage [ 11 ].…”
Section: Introductionmentioning
confidence: 99%