MicroRNA biogenesis in plant

Gao, Zihan; Nie, Jingtao; Wang, Huasen

doi:10.1007/s10725-020-00654-9

Cited by 27 publications

(11 citation statements)

References 142 publications

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“…MicroRNAs (miRNAs) are an important class of small, endogenous, noncoding, single-stranded, regulatory RNA molecules almost 21-24 nucleotides long and are produced from the precursors with intramolecular stem-loop structures through endonucleolytic processing [18]. The miRNAs are extensively distributed in biological organisms and are highly conserved (evolutionary) in plants [19,20]. Based on the sequence complementarity miRNAs bind to specific sites in the 3 ′ UTR region of the target mRNA and facilitate posttranscriptional silencing through degradation or/and translational inhibition of mRNA [19][20][21].…”

Section: Micrornas and Their Mode Of Actionmentioning

confidence: 99%

“…The miRNAs are extensively distributed in biological organisms and are highly conserved (evolutionary) in plants [19,20]. Based on the sequence complementarity miRNAs bind to specific sites in the 3 ′ UTR region of the target mRNA and facilitate posttranscriptional silencing through degradation or/and translational inhibition of mRNA [19][20][21].…”

Section: Micrornas and Their Mode Of Actionmentioning

confidence: 99%

“…miR397 has been reported to target members of the family laccase (LAC2, LAC4, and LAC17), the copper-containing enzymes regulating the diverse range of functions related to defense mechanism and lignification of the cell wall [88,89]. miR397 and miR398 are involved in both N and Cu homeostasis; however, under N stress, they 7 International Journal of Genomics get downregulated, while in response to Cu deficiency, they get upregulated [19]. Using massive sequencing and computational analyses, Liang et al [52] demonstrated that the laccase family is also the potential target for miR408 and miR857 which get downregulated in Arabidopsis under Nlimiting conditions.…”

Section: Mirnas and Their Targets Under Low Nmentioning

confidence: 99%

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miRNAomic Approach to Plant Nitrogen Starvation

Yousuf¹,

Shabir²,

Hakeem

2021

International Journal of Genomics

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Nitrogen (N) is one of the indispensable nutrients required by plants for their growth, development, and survival. Being a limited nutrient, it is mostly supplied exogenously to the plants, to maintain quality and productivity. The increased use of N fertilizers is associated with high-cost inputs and negative environmental consequences, which necessitates the development of nitrogen-use-efficient plants for sustainable agriculture. Understanding the regulatory mechanisms underlying N metabolism in plants under low N is one of the prerequisites for the development of nitrogen-use-efficient plants. One of the important and recently discovered groups of regulatory molecules acting at the posttranscriptional and translational levels are microRNAs (miRNAs). miRNAs are known to play critical roles in the regulation of gene expression in plants under different stress conditions including N stress. Several classes of miRNAs associated with N metabolism have been identified so far. These nitrogen-responsive miRNAs may provide a platform for a better understanding of the regulation of N metabolism and pave a way for the development of genotypes for better N utilization. The current review presents a brief outline of miRNAs and their regulatory role in N metabolism.

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Section: Micrornas and Their Mode Of Actionmentioning

confidence: 99%

Section: Micrornas and Their Mode Of Actionmentioning

confidence: 99%

Section: Mirnas and Their Targets Under Low Nmentioning

confidence: 99%

See 1 more Smart Citation

miRNAomic Approach to Plant Nitrogen Starvation

Yousuf¹,

Shabir²,

Hakeem

2021

International Journal of Genomics

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“…They are derived from single stranded (SS)-RNA and have a helical secondary structure [ 14 , 15 ]. Plants usually transcribe miRNAs from separate MIR genes by RNA polymerase II interactions, resulting in 5’ capped, 3’ polytailed miRNA molecules ( Figure 1 ) [ 16 ]. Dicer-like 1 (DCL1) proteins synthesize miRNAs from pri-miRNAs to create catalyst miRNAs, which are then recognized by other DCL1 proteins, which go on to form miRNA/miRNA* duplexes [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA Mediated Plant Responses to Nutrient Stress

Islam

Tauqeer

Waheed

et al. 2022

IJMS

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To complete their life cycles, plants require several minerals that are found in soil. Plant growth and development can be affected by nutrient shortages or high nutrient availability. Several adaptations and evolutionary changes have enabled plants to cope with inappropriate growth conditions and low or high nutrient levels. MicroRNAs (miRNAs) have been recognized for transcript cleavage and translational reduction, and can be used for post-transcriptional regulation. Aside from regulating plant growth and development, miRNAs play a crucial role in regulating plant’s adaptations to adverse environmental conditions. Additionally, miRNAs are involved in plants’ sensory functions, nutrient uptake, long-distance root transport, and physiological functions related to nutrients. It may be possible to develop crops that can be cultivated in soils that are either deficient in nutrients or have extreme nutrient supplies by understanding how plant miRNAs are associated with nutrient stress. In this review, an overview is presented regarding recent advances in the understanding of plants’ responses to nitrogen, phosphorus, potassium, sulfur, copper, iron, boron, magnesium, manganese, zinc, and calcium deficiencies via miRNA regulation. We conclude with future research directions emphasizing the modification of crops for improving future food security.

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“…The pri-miRNA folds back into a stem loop structure which is further processed into a pre-miRNA by DICER-LIKE1 (DCL1), HYPONASTIC LEAVES1 (HYL1), and SERRATE (SE) that is further processed to release the mature miRNA:miRNA ∗ duplex ( Voinnet, 2009 ). The duplex becomes 3′ methylated by HUA ENHANCER1 (HEN1) protecting the miRNA from degradation ( Yu et al, 2005 ; Gao et al, 2021 ). The mature miRNA strand binds to ARGONAUTE1 (AGO1) and is loaded into the RNA-induced silencing complex (RISC) guiding the complex to fully or partially reverse complementary target transcripts causing target cleavage or translational inhibition ( Voinnet, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Identification of Small RNAs During High Light Acclimation in Arabidopsis thaliana

et al. 2021

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The biological significance of non-coding RNAs (ncRNAs) has been firmly established to be important for the regulation of genes involved in stress acclimation. Light plays an important role for the growth of plants providing the energy for photosynthesis; however, excessive light conditions can also cause substantial defects. Small RNAs (sRNAs) are a class of non-coding RNAs that regulate transcript levels of protein-coding genes and mediate epigenetic silencing. Next generation sequencing facilitates the identification of small non-coding RNA classes such as miRNAs (microRNAs) and small-interfering RNAs (siRNAs), and long non-coding RNAs (lncRNAs), but changes in the ncRNA transcriptome in response to high light are poorly understood. We subjected Arabidopsis plants to high light conditions and performed a temporal in-depth study of the transcriptome data after 3 h, 6 h, and 2 days of high light treatment. We identified a large number of high light responsive miRNAs and sRNAs derived from NAT gene pairs, lncRNAs and TAS transcripts. We performed target predictions for differentially expressed miRNAs and correlated their expression levels through mRNA sequencing data. GO analysis of the targets revealed an overrepresentation of genes involved in transcriptional regulation. In A. thaliana, sRNA-mediated regulation of gene expression in response to high light treatment is mainly carried out by miRNAs and sRNAs derived from NAT gene pairs, and from lncRNAs. This study provides a deeper understanding of sRNA-dependent regulatory networks in high light acclimation.

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MicroRNA biogenesis in plant

Cited by 27 publications

References 142 publications

miRNAomic Approach to Plant Nitrogen Starvation

miRNAomic Approach to Plant Nitrogen Starvation

MicroRNA Mediated Plant Responses to Nutrient Stress

Identification of Small RNAs During High Light Acclimation in Arabidopsis thaliana

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