2008
DOI: 10.1007/s10522-008-9129-7
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Abstract: The Maillard reaction and its end products, AGE-s (Advanced Glycation End products) are rightly considered as one of the important mechanisms of post-translational tissue modifications with aging. We studied the effect of two AGE-products prepared by the glycation of lysozyme and of BSA, on the expression profile of a large number of genes potentially involved in the above mentioned effects of AGE-s. The two AGE-products were added to human skin fibroblasts and gene expression profiles investigated using micro… Show more

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Cited by 39 publications
(24 citation statements)
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References 20 publications
(22 reference statements)
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“…Interestingly, reduced HIF1a expression has also been reported in skin wounds of aged vs. young mice suffering diabetes (Liu, et al, 2008), a condition known to be a risk factor for age-related cerebrovascular disease (Kalaria, 2010). The heightened level of alpha 5 integrin Itga5 mRNA detected in aged cortex also supports the work of Lu et al (2004), who described a similar enhancement during transcriptional profiling of aged human frontal cortex, and may reveal action by age-associated advanced glycation endproducts (Molinari, et al, 2008). Increased expression of Flk1, Flt1 and Ang1 (the latter, a Tie2 ligand responsible for recruiting pericytes) at the NVU of aged cortex might further reflect compensatory changes to heighten VEGF responsiveness and stabilize aging cortical capillaries, respectively.…”
Section: 0 Discussionsupporting
confidence: 83%
“…Interestingly, reduced HIF1a expression has also been reported in skin wounds of aged vs. young mice suffering diabetes (Liu, et al, 2008), a condition known to be a risk factor for age-related cerebrovascular disease (Kalaria, 2010). The heightened level of alpha 5 integrin Itga5 mRNA detected in aged cortex also supports the work of Lu et al (2004), who described a similar enhancement during transcriptional profiling of aged human frontal cortex, and may reveal action by age-associated advanced glycation endproducts (Molinari, et al, 2008). Increased expression of Flk1, Flt1 and Ang1 (the latter, a Tie2 ligand responsible for recruiting pericytes) at the NVU of aged cortex might further reflect compensatory changes to heighten VEGF responsiveness and stabilize aging cortical capillaries, respectively.…”
Section: 0 Discussionsupporting
confidence: 83%
“…Indeed, this suggests that both 3DG and MG modify collagen differently and that the alteration in collagen expression is not due to the rate of modification by these AGE precursors. Our data further confirms the recent findings of Molinari et al (2008) who investigated the effects of AGE products on gene expression in dermal fibroblasts. AGEs alter the charge on collagen molecules (Hadley et al, 1998) and therefore may alter the interaction of collagen with its integrin binding receptor.…”
Section: Discussionsupporting
confidence: 92%
“…Activation of RAGE induces a down-regulation of genes involved in collagen synthesis and an up-regulation of matrix metalloproteinase-8 (MMP-8) and MMP-9 genes [20]. Furthermore, RAGE knockout mice demonstrate reduced MMP-9 activity [21].…”
Section: Introductionmentioning
confidence: 99%