2004
DOI: 10.1007/s10493-004-1389-6
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Abstract: Boophilus microplus has developed resistance against a range of chemical acaricides which has stimulated the development of alternative methods such as vaccination against ticks. In Cuba, the Bm86-based recombinant vaccine Gavac has been successfully used in a number of controlled laboratory and field trials in cattle against B. microplus. In this paper, we have evaluated Gavac in a large scale field trial wherein 588,573 dairy cattle were vaccinated with the aim to reduce the number of acaricidal treatments. … Show more

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Cited by 96 publications
(65 citation statements)
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“…Several anti-tick vaccines have been tested and the accumulated studies confirm that antibody response after vaccination correlates with protection against subsequent tick infestations (Willadsen et al 1995;Valle et al 2004;Leal et al 2006). Many studies have observed an increase in mortality rate in female ticks and/or a decrease in egg laying capacity after tick-protein vaccinations (Imamura et al , 2008Seixas et al 2008).…”
Section: Discussionmentioning
confidence: 99%
“…Several anti-tick vaccines have been tested and the accumulated studies confirm that antibody response after vaccination correlates with protection against subsequent tick infestations (Willadsen et al 1995;Valle et al 2004;Leal et al 2006). Many studies have observed an increase in mortality rate in female ticks and/or a decrease in egg laying capacity after tick-protein vaccinations (Imamura et al , 2008Seixas et al 2008).…”
Section: Discussionmentioning
confidence: 99%
“…It was observed that control of ticks by vaccination has the advantage of being cost-effective in reducing environmental contamination and preventing the selection of acaricide-resistant ticks. In addition, these vaccines may also prevent or reduce transmission of pathogens by reducing tick populations and/or affecting physiological functions of ticks (de la Fuente et al 1998(de la Fuente et al , 2007Das et al 2000, Rodriguez Valle et al 2004). Moreover, controlled immunization trials have shown Bm86-based vaccine having variable efficacy against different strains/isolates of R.…”
Section: Introductionmentioning
confidence: 99%
“…Combining analysis of the A. marginale genome sequence with mass-spectrometry-based protein sequencing and conventional antibody screening enabled the rapid identification of 24 additional antigenic proteins from this organism [40]. It is important also to recognize that anti-tick vaccines can directly and indirectly affect tick-transmitted disease [28,41]. Arguably, our ability to use current genomics information to best effect is limited by our poor understanding of what is necessary for an effective, protective immune response [42], although this will undoubtedly improve.…”
Section: Genomics and Traditional Biologymentioning
confidence: 99%