2011
DOI: 10.1007/s00705-011-1198-2
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Abstract: Human PSGL-1 is a receptor for EV71 that facilitates EV71 entry and replication in mouse cells. We have evaluated the role of human PSGL-1 in EV71 infection in vivo using a transgenic mouse line. Expression of human PSGL-1 failed to enhance infectivity of clinical EV71 strains in mice; however, it promoted replication and symptom severity at an earlier stage in mice upon infection with a mouse-adapted EV71 strain. We therefore conclude that human PSGL-1 alone is not sufficient to modulate infection with the cl… Show more

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Cited by 45 publications
(29 citation statements)
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“…Although previous reports had demonstrated that EV71 could infect hSCARB2-expressing cells more efficiently than the PSGL1-expressing cells [39], the host factors might be important and affect EV71 replication in different organs of the AAV-delivered mice. The hSCARB2 transgenic mice were reported to be more susceptible to EV71 infection than the hPSGL1 transgenic mice and resulted in significant neurological syndrome [24, 25, 40]; we did not observed these differences in this study.…”
Section: Discussioncontrasting
confidence: 54%
“…Although previous reports had demonstrated that EV71 could infect hSCARB2-expressing cells more efficiently than the PSGL1-expressing cells [39], the host factors might be important and affect EV71 replication in different organs of the AAV-delivered mice. The hSCARB2 transgenic mice were reported to be more susceptible to EV71 infection than the hPSGL1 transgenic mice and resulted in significant neurological syndrome [24, 25, 40]; we did not observed these differences in this study.…”
Section: Discussioncontrasting
confidence: 54%
“…SCARB2 plays all three roles, whereas PSGL1 does not have the ability to initiate EV71 uncoating. Therefore, PSGL1 alone is not sufficient to enhance EV71 infection in mice (32). Our preliminary results suggest that the transgenic expression of SCARB2 is sufficient to cause neurological diseases in mice.…”
Section: Discussionmentioning
confidence: 73%
“…Mouse cells that express PSGL1 are susceptible only to EV71-PB and CVA16 (18). However, the transgenic expression of PSGL1 in mice failed to confer susceptibility to EV71 in vivo (32).…”
mentioning
confidence: 99%
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“…Moreover, there is no evidence that other candidates can support viral infection as efficiently as SCARB2. Transgenic expression of human PSGL-1 in mice was not sufficient to permit EV71 infection (37). Together, these observations suggest that the expression of hSCARB2 in mice may confer susceptibility to EV71 infection.…”
mentioning
confidence: 74%