2007
DOI: 10.1007/s00705-006-0923-8
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Abstract: Neutralization is the ability of antibody to bind to and inactivate virus infectivity under defined conditions in vitro. Most neutralizing antibodies also protect animals in vivo, but protection is more complex as it also involves interaction of antibody with cells and molecules of the innate immune system. Neutralization by antibody can be mediated by a number of different mechanisms: by aggregation of virions, destabilization of the virion structure, inhibition of virion attachment to target cells, inhibitio… Show more

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Cited by 91 publications
(74 citation statements)
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“…These results were in line with multihit and coating models of virus neutralization, as opposed to single-hit models involving a critical site vulnerable to neutralization (6,32,33). However, such experiments are complicated by a convolution of cell-binding inhibition, inhibition of membrane fusion, aggregation of virus particles, and the abrogation of infection postentry (18,33).…”
Section: Significancesupporting
confidence: 71%
“…These results were in line with multihit and coating models of virus neutralization, as opposed to single-hit models involving a critical site vulnerable to neutralization (6,32,33). However, such experiments are complicated by a convolution of cell-binding inhibition, inhibition of membrane fusion, aggregation of virus particles, and the abrogation of infection postentry (18,33).…”
Section: Significancesupporting
confidence: 71%
“…Furthermore, at the institute where the serological analyses of the current study were performed, it was found that the addition of complement makes no or little difference to the outcome of the SNT. In support of the latter view, there are numerous mechanisms whereby antibodies can neutralise virus without the intervention of complement [31].…”
Section: Discussionmentioning
confidence: 96%
“…Cytosolic IgA-coated viruses are sufficient to activate NF-κB and induce proinflammatory cytokine secretion, and this may be important in detecting virions that otherwise escape invariant pattern recognition receptors such as Toll-like receptors. The interaction of mIgA and dIgA with FcαRI has been shown to stimulate NF-κB signaling; however, FcαRI is only expressed by myeloid cells (7,28). By contrast, TRIM21 is universally expressed and thus may allow IgA to stimulate innate immunity without relying on immune surveillance.…”
Section: Discussionmentioning
confidence: 99%
“…However, FcαRI, like most Fc receptors, is exclusively expressed on professional myeloid cells (5,6). Viral neutralization is mediated by antibodies whose in vitro binding to a virus can cause a reduction in infectious titer independently of effector mechanisms such as Fc-mediated phagocytosis or complement fixation (7). Recently, we discovered a neutralization pathway mediated by the cytosolic antibody receptor, tripartite motif-containing protein 21 (TRIM21), which is expressed in most tissue types and not just professional cells (8,9).…”
mentioning
confidence: 99%