The WHO/ISUP 1998 and WHO 1999 systems for malignancy grading of bladder cancer. Scientific foundation and translation to one another and previous systems

Busch, Christer; Algaba, Ferrán

doi:10.1007/s00428-002-0633-x

Cited by 73 publications

(43 citation statements)

References 12 publications

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“…41,42 Moreover, it remains to be seen whether the revised histopathologic classification of urothelial tumors, though designed for better discrimination between the biologic potentials of bladder neoplasms, will lead to changes in the management of bladder cancer patients. 38,38,43 This issue is discussed controversially, 39,40,44,45 and the clinical significance of identifying lesions of low malignant potential remains to be established. 39,43 Nevertheless, the consequences of missing a small low-grade pTa tumor seem acceptable.…”

Section: Discussionmentioning

confidence: 99%

Quantitative evaluation of telomerase subunits in urine as biomarkers for noninvasive detection of bladder cancer

Weikert

Krause

Wolff

et al. 2005

Intl Journal of Cancer

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The aim of our study was to prospectively evaluate the potential diagnostic value and clinical applicability of quantitative analysis of telomerase subunits gene expression in urine for noninvasive detection of bladder cancer. Expression levels of human telomerase reverse transcriptase (hTERT) and human telomerase RNA (hTR) were analyzed by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in urine samples from 163 subjects with bladder cancer and 237 controls (163 individuals with benign genitourinary diseases; 74 healthy subjects). The sensitivity, specificity and optimal cutoffs were determined and compared to the corresponding values obtained by voided urine cytology. Quantitative urinary hTR analysis detects bladder cancer with an overall sensitivity of 77.0%, whereas hTERT analysis reached a sensitivity of 55.2%. The majority of undetected tumors were small, lowgrade pTa lesions. Both hTR and hTERT proved to be significantly more sensitive than cytology (34.5%; p < 0.001). Specificities for hTR, hTERT and cytology were 72.1%, 85.0% and 92.7%, respectively, in the total study population and 96.9%, 89.2% and 100%, respectively, in healthy subjects. Higher diagnostic accuracy was achieved by hTR than by hTERT analysis (p < 0.05). The specificity of hTR increased to 85.0% in the total population if urinary leukocyte contamination was excluded. These data suggest that quantitative hTR analysis is the most accurate telomerase-based test for bladder cancer detection and has the potential to replace cytology as a noninvasive biomarker for disease diagnosis and follow-up. ' 2005 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Quantitative evaluation of telomerase subunits in urine as biomarkers for noninvasive detection of bladder cancer

Weikert

Krause

Wolff

et al. 2005

Intl Journal of Cancer

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“…At this time, no patient showed clinical evidence of infection, or other inflammatory conditions. Tumour stage was assessed using the 1997 AJCC/UICC TNM classification (Sobin and Wittekind, 1997), and tumour grade was performed according to the 1999 WHO grading system (Busch and Algaba, 2002).…”

Section: Methods Patientsmentioning

confidence: 99%

The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic infiltration and COX-2 expression and survival in patients with transitional cell carcinoma of the urinary bladder

et al. 2006

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The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic infiltration, and COX-2 expression and survival was examined in patients with transitional cell carcinoma of the urinary bladder (n ¼ 103). Sixty-one patients had superficial disease and 42 patients had invasive disease. Cancer-specific survival was shorter in those patients with invasive compared with superficial bladder cancer (Po0.001). On univariate analysis, stratified by stage, increased Ki-67 labelling index (Po0.05), increased COX-2 expression (Po0.05), C-reactive protein (Po0.05) and adjuvant therapy (Po0.01) were associated with poorer cancer-specific survival. On multivariate analysis of these significant factors, stratified by stage, only C-reactive protein (HR 2.89, 95% CI 1.42 -5.91, P ¼ 0.004) and adjuvant therapy (HR 0.29, 95% CI 0.14 -0.62, P ¼ 0.001) were independently associated with poorer cancer-specific survival. These results would suggest that tumour-based factors such as grade, COX-2 expression or T-lymphocytic infiltration are subordinate to systemic factors such as C-reactive protein in determining survival in patients with transitional cell carcinoma of the urinary bladder.

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“…Le grade 2 constitue ainsi un grade intermédiaire situé entre les deux extrêmes du spectre, regroupant des tumeurs hétérogènes et dans lequel les pathologistes tendent à classer la majorité des tumeurs 5,6 . Les proportions des tumeurs G2 varient de 13 à 69 % selon les séries 7,8 .…”

Section: Discussionunclassified

Reproductibilité des classifications OMS 1973 et OMS 2004 des tumeurs urothéliales papillaires de la vessie

Abdelkrim

Rammeh

Trabelsi

et al. 2012

CUAJ

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E230Cite as: Can Urol Assoc J 2012;6:E230-E233. http://dx.doi.org/10.5489/cuaj.10078. Epub 2011 Sept 8. Résumé Methods:One hundred and two cases of pTa/pT1 papillary urothelial bladder tumours were evaluated retrospectively. Two pathologists reviewed the slides and assigned a tumour grade according to the 1973 and the 2004 WHO classifications. Whenever a discrepancy was noted between the first and the second reading, the two pathologists together reviewed the slides and reached a consensus for the final grading according to the two classifications. Intraobserver variability was assessed by one of the two pathologists who reviewed the slides one month later. Interpretive discrepancies for each category of neoplasm were documented. Degree of agreement and reproducibility were evaluated using intra-and inter-rater techniques (kappa statistic). A value of 0.21-0.40 was accepted as weak, 0.41-0.60 as moderate, 0.61-0.80 as substantial and 0.81-1 as absolute agreement. Results: According to the 1973 WHO classification, the proportions of G1, G2 and G3 tumours were 40.2%, 50% and 9.8%, respectively. According to the 2004 WHO classification, the proportions of tumours of low malignant potential, low-grade carcinomas, and high-grade carcinomas were 23.5%, 60.8% and 15.7%, respectively. The intra-observer reproducibility was excellent for the two classifications (absolute agreement). The degree of agreement between pathologists was higher in the 2004 WHO (kappa = 0.7) than the 1973 WHO classification (kappa = 0.51). Conclusions:The present findings suggest that the new proposed classification system for urothelial papillary neoplasms slightly increases the inter-observer reproducibility. The intra-observer reproducibility is excellent for the two classifications.

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The WHO/ISUP 1998 and WHO 1999 systems for malignancy grading of bladder cancer. Scientific foundation and translation to one another and previous systems

Cited by 73 publications

References 12 publications

Quantitative evaluation of telomerase subunits in urine as biomarkers for noninvasive detection of bladder cancer

Quantitative evaluation of telomerase subunits in urine as biomarkers for noninvasive detection of bladder cancer

The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic infiltration and COX-2 expression and survival in patients with transitional cell carcinoma of the urinary bladder

Reproductibilité des classifications OMS 1973 et OMS 2004 des tumeurs urothéliales papillaires de la vessie

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