Co-existent ovarian mucinous cystadenocarcinoma and ovarian choriocarcinoma

Jiménez‐Heffernan, José A.; Perna, Cristian; Martínez, Alejandra; Casinello, J.; Cuevas, J.

doi:10.1007/s004040100211

Cited by 10 publications

(12 citation statements)

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“…Such cases have been reported as epithelial ovarian carcinomas of a "non-germ cell origin" with "choriocarcinomatous differentiation"; however, detailed genetic analyses have not been performed. [4][5][6][7] In the present case, an STR analysis of the adenocarcinoma component showed the same homozygous patterns as those of the choriocarcinoma component. These results indicated that the choriocarcinoma and adenocarcinoma components were of the same cellular origin (i.e.…”

Section: Detailed Genetic Analysessupporting

confidence: 60%

“…On the other hand, ovarian choriocarcinomas co‐existing with adenocarcinoma are extremely rare. Such cases have been reported as epithelial ovarian carcinomas of a “non‐germ cell origin” with “choriocarcinomatous differentiation”; however, detailed genetic analyses have not been performed . In the present case, an STR analysis of the adenocarcinoma component showed the same homozygous patterns as those of the choriocarcinoma component.…”

Section: Discussionsupporting

confidence: 44%

“…Teratomas co‐existing with mucinous carcinoma have sometimes been reported, and two recent studies revealed that these components were of the same germ cell origin using molecular genetic approaches . However, ovarian non‐gestational choriocarcinomas co‐existing with adenocarcinoma are extremely rare and have been reported as epithelial ovarian carcinomas of a “non‐germ cell origin” with “choriocarcinomatous differentiation” . Although the cellular origin of non‐gestational choriocarcinoma may be post‐meiotic ovarian germ cells (germ cell origin) or the dedifferentiation of epithelial ovarian carcinoma (somatic cell origin), detailed genetic analyses have rarely been performed.…”

mentioning

confidence: 99%

“…2,3 However, ovarian non-gestational choriocarcinomas co-existing with adenocarcinoma are extremely rare and have been reported as epithelial ovarian carcinomas of a "non-germ cell origin" with "choriocarcinomatous differentiation". [4][5][6][7] Although the cellular origin of non-gestational choriocarcinoma may be post-meiotic ovarian germ cells (germ cell origin) or the dedifferentiation of epithelial ovarian carcinoma (somatic cell origin), detailed genetic analyses have rarely been performed. A DNA polymorphism analysis is considered useful for determining the genetic origin of various tumors.…”

mentioning

confidence: 99%

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Ovarian nongestational choriocarcinoma and associated adenocarcinoma with the same germ cell origin determined by a molecular genetic approach: A case report

Koyanagi

Fujiwara

Usui

et al. 2016

Pathology International

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Ovarian non-gestational choriocarcinomas co-existing with adenocarcinoma are extremely rare and have been reported as epithelial ovarian carcinomas of a "non-germ cell origin" with "choriocarcinomatous differentiation". Although the cellular origin of non-gestational choriocarcinoma may be post-meiotic ovarian germ cells or the dedifferentiation of epithelial ovarian carcinoma, detailed genetic evidence has not yet been obtained to support this. We herein present a case of ovarian non-gestational choriocarcinoma co-existing with adenocarcinoma in a 29-year-old woman. The tumor rapidly increased in size and lung metastases appeared soon after parturition. We genetically demonstrated that the cellular origin of ovarian non-gestational choriocarcinoma was a post-meiotic germ cell derivation using a short tandem repeat analysis. The co-existing adenocarcinoma component was also shown to be of the same germ cell origin. These tumors showed the same homozygous pattern. A molecular genetic approach may be important for understanding the clinicopathological features of such tumors.

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Section: Detailed Genetic Analysessupporting

confidence: 60%

Section: Discussionsupporting

confidence: 44%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Ovarian nongestational choriocarcinoma and associated adenocarcinoma with the same germ cell origin determined by a molecular genetic approach: A case report

Koyanagi

Fujiwara

Usui

et al. 2016

Pathology International

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“…The second hypothesis is that of a divergent differentiation of a serous carcinoma called as “neometaplastic” process or as “retrodifferentiation” or “dedifferentiation” [ 3 , 4 , 7 ]. Such an origin is favored because a transition zone can be identified in some cases as in our case [ 3 , 6 ].…”

Section: Discussionmentioning

confidence: 97%

Double Pathology: Malignant Epithelial Ovarian Tumor and Germ Cell Tumor (Choriocarcinoma), a Rare Coexistence

et al. 2015

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Surface epithelial stromal tumors account for approximately 60% of all ovarian tumors and approximately 90% of all ovarian malignancies. Sex cord stromal tumors account for 7% of all malignant ovarian tumors. Germ cell tumors make up only 3-7% of malignant ovarian tumors. A combination of serous carcinoma of the ovary and choriocarcinoma is rare. Until today such combination has been documented only in six cases in the English literature. Here, we describe a case of ovarian serous carcinoma, where histopathology revealed a combination of serous carcinoma with adjacent choriocarcinoma component in the extraovarian peritoneal deposits. A 64-year-old post-menopausal female was diagnosed to have stage IV ovarian cancer. She received six cycles chemotherapy. Subsequently she underwent optimal cytoreductive surgery. Microscopically, monomorphic histology (serous carcinoma) was noted in both the ovaries and dimorphic histologies (serous carcinoma and choriocarcinoma) in the sigmoid mesocolon nodule, omentum and left subdiaphragmatic nodules. Metronomic chemotherapy continued and patient is on regular follow-up for the past 1 year with stable disease. Recognition of choriocarcinomatous components in ovarian carcinomas is important because of its association with aggressive behavior. In spite of the aggressive histology, the patient is surviving for the past 1 year. Different chemotherapeutic regimens have been used in cases of mixed choriocarcinoma and carcinoma, but established chemotherapeutic regimens have not been described. Chemotherapeutic regimens that target both components have been advocated and used. The absence of choriocarcinoma in ovarian primary and its presence in the extraovarian peritoneal deposits have not been described in the English literature so far. This case is being presented for its rarity.

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Endometrioid carcinoma of the endometrium with choriocarcinomatous differentiation: a case report and review of the literature

Akbulut

Tosun

Soysal

et al. 2007

Arch Gynecol Obstet

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Co-existent ovarian mucinous cystadenocarcinoma and ovarian choriocarcinoma

Cited by 10 publications

References 0 publications

Ovarian nongestational choriocarcinoma and associated adenocarcinoma with the same germ cell origin determined by a molecular genetic approach: A case report

Ovarian nongestational choriocarcinoma and associated adenocarcinoma with the same germ cell origin determined by a molecular genetic approach: A case report

Double Pathology: Malignant Epithelial Ovarian Tumor and Germ Cell Tumor (Choriocarcinoma), a Rare Coexistence

Endometrioid carcinoma of the endometrium with choriocarcinomatous differentiation: a case report and review of the literature

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