Value of endometrial thickness assessed by transvaginal ultrasound for the prediction of endometrial cancer in patients with postmenopausal bleeding

Schramm, A; Ebner, Florian; Bauer, Elena; Janni, Wolfgang; Friebe-Hoffmann, U; Pellegrino, Miriam; Gregorio, Nikolaus de; Friedl, Thomas

doi:10.1007/s00404-017-4439-0

Cited by 19 publications

(10 citation statements)

References 32 publications

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“…Transvaginal ultrasonography (TVS) is the imaging modality of choice for the initial evaluation of suspected EC (5). Measurement of endometrial thickness (ET) using TVS is non-invasive, precise and sensitive, and is particularly useful when the endometrium is homogenous (21). Its diagnostic utility for EC is, however, limited by a low specificity, as a thickened endometrium may be caused by other pathologies including endometrial polyps, intracavitary fibroids and artefacts such as blood clots, and is seen in approximately 50% of women undergoing TVS for suspected EC (21)(22)(23).…”

Section: The Diagnosis Of Endometrial Cancermentioning

confidence: 99%

Urinary Biomarkers and Their Potential for the Non-Invasive Detection of Endometrial Cancer

et al. 2020

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Endometrial cancer is the most common malignancy of the female genital tract and its incidence is rising in parallel with the mounting prevalence of obesity. Early diagnosis has great potential to improve outcomes as treatment can be curative, especially for early stage disease. Current tests and procedures for diagnosis are limited by insufficient accuracy in some and unacceptable levels of invasiveness and discomfort in others. There has, therefore, been a growing interest in the search for sensitive and specific biomarkers for endometrial cancer detection based on non-invasive sampling methodologies. Urine, the prototype non-invasive sample, is attractive for biomarker discovery as it is easily accessible and can be collected repeatedly and in quantity. Identification of urinary biomarkers for endometrial cancer detection relies on the excretion of systemic biomarkers by the kidneys or urinary contamination by biomarkers shed from the uterus. In this review, we present the current standing of the search for endometrial cancer urinary biomarkers based on cytology, genomic, transcriptomic, proteomic, and metabolomic platforms. We summarize the biomarker candidates and highlight the challenges inherent in urinary biomarker discovery. We review the various technologies with promise for biomarker detection and assess these novel approaches for endometrial cancer biomarker research.

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Section: The Diagnosis Of Endometrial Cancermentioning

confidence: 99%

Urinary Biomarkers and Their Potential for the Non-Invasive Detection of Endometrial Cancer

et al. 2020

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“… 12 Ultrasound variables with clinical and laboratory parameters has been studies to predict endometrial cancers in various studies. 13 14 However benign endometrial lesions and normal endometrial variants are difficult to diagnose with grey scale ultrasonographic examination alone. Study comparing Saline Infusion Sonography (SIS) and hysteroscopy for detection of uterine abnormalities concluded that these abnormalities were significantly less likely to be identified with SIS compared to hysteroscopy (P = 0.002).…”

Section: Discussionmentioning

confidence: 99%

Establishing patterns on hysteroscopy in abnormal uterine bleeding (AUB)

Pandey

Kunamneni

Inukollu

et al. 2017

Gynecology and Minimally Invasive Therapy

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Introduction:Pattern recognition of various phases of normal endometrium and endometrial pathologies during hysteroscopy has many advantages. It would help to triage women with AUB, so as to be selective with biopsies and curettages. Recognition of normal variant or benign lesion would reduce burden to the pathologist by decreasing the number of unnecessary sampling. It will also decreases anxiety of the patient as the report/prognostication can be instant in many cases.Material and methods:This prospective, double blind, correlation study was carried out in the teaching hospital with a sample population of 70 women presenting with AUB who underwent hysteroscopy and endometrial sampling. We identified patterns of endometrium which can used to predict six endometrial pathologies which were later correlated with the final histological diagnosis.Results:There was good correlation between hysteroscopic patterns and histopathology report, 33% of starry sky appearance correlated with atrophic endometrium, 87% of tongue shaped projections correlated with endometrial polyp, 44.4% of pebble stone appearance correlated with myomatous polyp, 50% of polypoidal pattern correlated with endometrial hyperplasia. 100% correlation was seen in strawberry appearance, pattern for secretory endometrium and cerebroid appearance which was pattern designated to endometrial carcinoma.Conclusion:Hysteroscopic pattern recognition is a useful concept to triage women who require sampling for histopathological diagnosis.

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“…Post-menopausal Bleeding is recurrent occasion within postmenopausal females as well as signifies upto 10% of whole appointments into secluded practice of gynecology. Incidence of Post-menopausal Bleeding within entire post-menopausal females is about 10%, frequently produced through benign results for instance Endometrial Hyperplasia /Atrophy/Benign Bolyps 1,2 . Though, Post-menopausal Bleeding is too extremely doubtful of existence a mark intended for EC presence as well as about 5% to 12% of Post-menopausal Bleeding consequences from endometrial cancer 3 .…”

Section: Introductionmentioning

confidence: 99%

Ultrasound Measurement of Endometrial Thickness for Detecting Endometrial Malignancy

Iqbal¹,

Murrium²,

Yaseen³

et al. 2021

PJMHS

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Background: Post-menopausal Bleeding is extremely doubtful of existence a mark intended for incidence of EC as well as around 5% to 12% of post-menopausal bleeding consequences commencing endometrial cancer. EC is greatest communal Gynecologic Malignancy into established countries. Thin endometrium (≤4 mm) devours precise high NPV (99%). Thickened Endometrium has been considered by way of sign intended for an offensive assessment. Aim: To determine the ET measurement for detecting endometrial malignancy with uterine bleeding in post-menopausal females. Methods: The search was led according to Systematic Reviews Ethics. Searched databases were: Google scholar and Web Research from January 2014 and November 2020. Around nine studies were designated for this Systemic Review. We mined subsequent facts: Design of study, mean age and range, menopause duration, range and mean, BMI range and mean, as well as ET range and mean. Conclusion: From beyond examination this review concluded that, the Endometrial Thickness among the suggested alteration in cut off 3-5 mm within repetitive ultrasound practice must be ended in elevation threat females identify for malignancy before in Postmenopausal females as well as ultrasound is attested chosen a convenient implement to diagnose. Keywords: Post-menopausal Bleeding, Endometrial Thickness, Endometrial Cancer.

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Value of endometrial thickness assessed by transvaginal ultrasound for the prediction of endometrial cancer in patients with postmenopausal bleeding

Abstract: There is no ET cutoff point that provides good diagnostic accuracy and/or reliably excludes the presence of endometrial cancer in patients with PMB. Thus, our data analysis supports the actual German approach of histological evaluation of any PMB to confirm or exclude EC.

Cited by 19 publications

References 32 publications

Urinary Biomarkers and Their Potential for the Non-Invasive Detection of Endometrial Cancer

Urinary Biomarkers and Their Potential for the Non-Invasive Detection of Endometrial Cancer

Establishing patterns on hysteroscopy in abnormal uterine bleeding (AUB)

Ultrasound Measurement of Endometrial Thickness for Detecting Endometrial Malignancy

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