Preparation of nanogels based on kappa-carrageenan/chitosan and N-doped carbon dots: study of drug delivery behavior

Rahmani, Zeinab; Ghaemy, Mousa; Olad, Ali

doi:10.1007/s00289-020-03236-x

Cited by 20 publications

(3 citation statements)

References 30 publications

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“…The polysaccharides κ-carrageenan and chitosan, containing anion-sulfate and amino groups, respectively, provide electrostatic interactions with drugs used to treat neurodegenerative diseases—Alzheimer’s disease and Parkinson’s disease. In [ 96 ], rivastigmine was incorporated into a nanogel based on chitosan and κ-carrageenan. The κ-carrageenan was added to chitosan to reduce the solubility of chitosan in the acidic environment of the stomach.…”

Section: Gels For the Treatment Of Neurodegenerative Diseasesmentioning

confidence: 99%

Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

et al. 2023

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Modified polymeric gels, including nanogels, which play not only the role of a bioinert matrix, but also perform regulatory, catalytic, and transport functions due to the active fragments introduced into them, can significantly advance the solution to the problem of targeted drug delivery in an organism. This will significantly reduce the toxicity of used pharmaceuticals and expand the range of their therapeutic, diagnostic, and medical application. This review presents a comparative description of gels based on synthetic and natural polymers intended for pharmaceutical-targeted drug delivery in the field of therapy of inflammatory and infectious diseases, dentistry, ophthalmology, oncology, dermatology, rheumatology, neurology, and the treatment of intestinal diseases. An analysis was made of most actual sources published for 2021–2022. The review is focused on the comparative characteristics of polymer gels in terms of their toxicity to cells and the release rate of drugs from nano-sized hydrogel systems, which are crucial initial features for their further possible application in mentioned areas of biomedicine. Different proposed mechanisms of drug release from gels depending on their structure, composition, and application are summarized and presented. The review may be useful for medical professionals, and pharmacologists dealing with the development of novel drug delivery vehicles.

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Section: Gels For the Treatment Of Neurodegenerative Diseasesmentioning

confidence: 99%

Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

et al. 2023

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“…Rahmani et al 43 developed pH-responsive nanogels that incorporate rivastigmine as a representative drug model. The nanogels were created by the graft polymerizing method, deploying acrylamide and sodium acrylate monomers onto chitosan (CS) and kappa-carrageenan (CG or κ-carrageenan) structures.…”

Section: Polysaccharide-based Nanogels For Drug Deliverymentioning

confidence: 99%

Smart stimuli-responsive polysaccharide nanohydrogels for drug delivery: a review

Damiri,

Fatimi,

Santos

et al. 2023

J. Mater. Chem. B

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“…As expected, the release was weaker at pH 1.2. Carbon dot-containing NGs were biocompatible giving rise to high percentages of primary human fibroblast cells viability up to concentration 62.5 μg/mL [ 90 ].…”

Section: Medical Applications Of Polysaccharide Ngs and Mgsmentioning

confidence: 99%

Current Advances of Polysaccharide-Based Nanogels and Microgels in Food and Biomedical Sciences

Papagiannopoulos

Sotiropoulos²

2022

Polymers

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Polysaccharides are natural polymers with hydrophilic, biocompatible and biodegradable characteristics and have many opportunities in the food and pharmaceutical sectors. This review focuses on the field of nano and microstructures whose internal structure is based on networked polysaccharide chains in 3D i.e., polysaccharide nanogels (NGs) and microgels (MGs). As it is observed the number of articles on NGs and MGs in peer reviewed scientific journals has been increasing over the last two decades. At the same time, the relative contribution of polysaccharides in this field is gaining place. This review focuses on the different applied methods for the fabrication of a variety of polysaccharide-based NGs and MGs and aims to highlight the recent advances on the subject and present their potentials and properties with regards to their integration in aspects of medicinal and food sciences. The presentation of the recent advances in the application of polysaccharide NGs and MGs is divided in materials with potential as emulsion stabilizers and materials with potential as carriers of bioactives. For applications in the medical sector the division is based on the fabrication processes and includes self-assembled, electrostatically complexed/ionically crosslinked and chemically crosslinked NGs and MGs. It is concluded that many advances are expected in the application of these polysaccharide-based materials and in particular as nutrient-loaded emulsion stabilizers, viscosity modifiers and co-assembled structures in combination with proteins.

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Preparation of nanogels based on kappa-carrageenan/chitosan and N-doped carbon dots: study of drug delivery behavior

Cited by 20 publications

References 30 publications

Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

Smart stimuli-responsive polysaccharide nanohydrogels for drug delivery: a review

Current Advances of Polysaccharide-Based Nanogels and Microgels in Food and Biomedical Sciences

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