2011
DOI: 10.1007/s00223-010-9449-x
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Abstract: Purpose Calcium plus vitamin D (CaD) supplementation has a modest but significant effect on slowing loss of femoral bone mass and reducing risk of hip fractures in adherent postmenopausal women. The goal of this study was to determine if CaD supplementation influences hip structural parameters that are associated with fracture risk. Methods We studied 1,970 postmenopausal women enrolled in the Women’s Health Initiative randomized controlled trial of CaD at one of three bone mineral density (BMD) clinical cen… Show more

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Cited by 15 publications
(5 citation statements)
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“…Using NHANES 2003–2006 data, we assume that in the absence of any supplementation, subjects’ daily, dietary intake was at least calcium 1000 mg/day and vitamin D 200 IU/day (46). Data from non-diabetic postmenopausal women in the WHI show that calcium 1000mg and vitamin D 400 IU daily supplementation has favorable effects on hip geometry parameters (47). Further studies are needed to determine whether similar supplementation in men and women with T2DM could have similar, beneficial effects on hip strength.…”
Section: Discussionmentioning
confidence: 99%
“…Using NHANES 2003–2006 data, we assume that in the absence of any supplementation, subjects’ daily, dietary intake was at least calcium 1000 mg/day and vitamin D 200 IU/day (46). Data from non-diabetic postmenopausal women in the WHI show that calcium 1000mg and vitamin D 400 IU daily supplementation has favorable effects on hip geometry parameters (47). Further studies are needed to determine whether similar supplementation in men and women with T2DM could have similar, beneficial effects on hip strength.…”
Section: Discussionmentioning
confidence: 99%
“…The Women's Health Initiative (WHI) enrolled 161,808 postmenopausal women between the ages of 50 and 79 years at baseline at 40 clinical centers for clinical trials and an observational study. Here, we focused on the WHI DXA cohort, a group of women for whom dual‐energy X‐ray absorptiometry (DXA) was measured at one of three clinical centers (Pittsburgh, PA; Birmingham, AL; Tucson/Phoenix, AZ) . Approximately 11,323 women had a complete DXA scan at the WHI baseline visit.…”
Section: Methodsmentioning
confidence: 99%
“…Here, we focused on the WHI DXA cohort, a group of women for whom dual-energy X-ray absorptiometry (DXA) was measured at one of three clinical centers (Pittsburgh, PA; Birmingham, AL; Tucson/Phoenix, AZ). (8) Approximately 11,323 women had a complete DXA scan at the WHI baseline visit. After excluding 239 women with incomplete sleep data, we had a final sample of 11,084 women.…”
Section: Study Populationmentioning
confidence: 99%
“…Recent studies have also demonstrated that vitamin D and calcium supplementation have some limited effects on some geometrical features of the bones, other than BMD, that correlate with bone resistance. In particular a structural analysis of the femur in a subgroup of female patients investigated in the Women's Health initiative trial has shown that calcium plus vitamin D supplementation preserves BMD better than placebo and can increase the cross-sectional area and the section modulus of the femur neck, which are geometrical properties inversely correlated with the risk of hip fracture (16). However the most important aspect of vitamin D supplementation is its capacity of reducing the risk of fracture.…”
Section: N Vitamin D and Osteoporosismentioning
confidence: 99%