The developmental origins of sarcopenia

Sayer, Avan A.; Syddall, Holly; Martin, Helmut; Patel, Harnish P.; Baylis, D.; Cooper, Cyrus

doi:10.1007/bf02982703

Cited by 325 publications

(227 citation statements)

References 48 publications

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“…This apparently contradictory result may be explained by natural physiological differences, as our study sample includes only young adults (mean age 21 year-old). Contrary to older people and children, young adults have a larger variation in muscle mass and generally higher muscle mass content (Sayer et al, 2008) so the change caused by exercise has an effect on body composition rather than total mass (Westerterp, 2013). As BMI variations are mostly the effect of the muscle to fat mass proportions, the observed significant increase in BMI under physically activity, mainly in young adults homozygous for the major genotype TT, could be due to an increase in lean (muscle) mass rather than in fat mass.…”

Section: Discussionmentioning

confidence: 86%

Influence of physical activity on the association between the FTO variant rs9939609 and adiposity in young adults

Muc

Padez

Manco

2015

American J Hum Biol

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Objectives: To investigate in a population sample of Portuguese young adults the association of the FTO variant rs9939609 with obesity, BMI and body-fat and interaction with physical activity (PA) on obesity-susceptibility.Methods: SNP rs9939609 A/T was genotyped in 550 subjects (231 males and 319 females; 18-36 year-old; mean age 21 year-old) by TaqMan assay. PA was assessed with a validated self-reported questionnaire of IPAQ. Results:We replicated the association of rs9939609-A risk allele with BMI (P=0.04) and fat-mass (P=0.031), and with overweight (including obesity) under a recessive model (P=0.034). Stratified analyses showed i) a significant association with overweight/obesity in inactive individuals (P=0.02) but not in a group reporting sport practicing (P=0.97). Spearman's correlation test suggested that the impact of a successive increase in PA is a decrease in the body-fat percentage (r=-0.16; P=0.0002), which is more accentuated for homozygous AA (r=-0.34; P=0.002), and an increase in BMI (r=0.14; P=0.001), with a statistically significant correlation for homozygous TT (r=0.22; P=0.002). Conclusions:This study reveals interactions between rs9939609 and PA on obesity indices in Portuguese young adults, suggesting a change in the different body components (lean and fat mass) depending on the FTO genotypes.

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Section: Discussionmentioning

confidence: 86%

Influence of physical activity on the association between the FTO variant rs9939609 and adiposity in young adults

Muc

Padez

Manco

2015

American J Hum Biol

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“…These include age, genetic factors, muscle crosssection, gender, malnutrition, health status and associated disease, behavioral factors such as levels of physical activity, smoking, hormonal factors, the concentration of vitamin D, the concentration of cytokines, and even race [9,[34][35][36][37]. Health status and concomitant diseases are associated with quality of muscle work.…”

Section: Muscle Function Is Debilitated In Many Diseasesmentioning

confidence: 99%

May the Power Be With Us

Kostka¹

2013

Aging Sci

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“…Muscle mass develops up to the age of 20 and 30 years, and is relatively maintained throughout adult life. As one ages, muscle mass decreases and one reaches a threshold whereby low muscle mass will inevitably lead to disability and future complications (Sayer et al 2008). Assessing sarcopenia has been a challenge in the research literature.…”

Section: Muscle Changes With Aging -Sarcopeniamentioning

confidence: 99%