Method for the rapid estimation of the total body drug clearance and adjustment of dosage regimens in patients during a constant-rate intravenous infusion

Chiou, Win L.; Gadalla, M. A. F.; Peng, Geoffrey W.

doi:10.1007/bf01117448

Cited by 64 publications

(25 citation statements)

References 10 publications

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“…4). The pharmacokinetic findings concerning 1,3-DMX are in good agreement with those previously reported in the rabbit (21). About 90% (67-112%) of the 1,3-DMX dose was recovered in the urine within 48 h (Fig.…”

Section: Resultssupporting

confidence: 81%

Pharmacokinetics of theophylline and its metabolites in rabbits

Celardo

Traina

Jankowski

et al. 1985

European Journal of Drug Metabolism and Pharmacokinetics

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The pharmacokinetics of theophylline (1,3-DMX) and its metabolites were investigated in detail in four male rabbits after bolus intravenous injection (12 mg/kg) of the compound. Theophylline was measured in blood and urine, and its metabolites were determined only in urine. Apparent first-order rate constants for the metabolic processes involved in the formation of 1,3-DMX metabolites and their excretion in urine were calculated. An appropriate 13-compartment model was formulated to describe the disposition of 1,3-DMX and its metabolites.

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Section: Resultssupporting

confidence: 81%

Pharmacokinetics of theophylline and its metabolites in rabbits

Celardo

Traina

Jankowski

et al. 1985

European Journal of Drug Metabolism and Pharmacokinetics

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“…An additional loading dose was given ifnecessary based on theophylline measurement. The maintenance dose was adjusted using the formula proposed by Chiou et al (1978).…”

Section: Methodsmentioning

confidence: 99%

Theophylline Target Concentration in Severe Airways Obstruction - 10 or 20 mg/L?

Holford

Black

Couch

et al. 1993

Clinical Pharmacokinetics

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The optimal serum concentration of theophylline for the management of acute airways obstruction was evaluated by comparing the response to target concentrations at the extremes of the usual therapeutic range. 174 patients requiring intravenous theophylline were randomly assigned to a target concentration of 10 or 20 mg/L. Control of theophylline dosage using measured theophylline concentrations and evaluation of efficacy and toxicity was performed under double-blind conditions. 87 patients (50%) required hospital admission. Of these, 54 patients (62%) were followed throughout their hospital admission and reviewed at an outpatient clinic approximately 1 week after discharge. The duration of hospital stay, and rate and extent of improvement in peak expiratory flow rate were not different between the groups. There was significantly more toxicity in the 20 mg/L group. The initial target concentration for theophylline in the management of acute airway obstruction should be 10 mg/L under circumstances where concentration is used to control theophylline dosages.

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“…Using a rapid microbiological method or rapid test, the result for serum gentamicin concentration could be obtained before the infusion bottle is changed at 24 h. As described in detail by Chiou et al [17] it is possible to estimate plasma clearance before steady state is obtained using a Vd based on literature data and rapid assay methods with a coefficient of variation of about 6%. The method for rapid estimation of clearance could therefore presumably be used for newborn infants.…”

Section: Discussionmentioning

confidence: 99%

Kinetics and Dose Calculations of Ampicillin and Gentamicin Given as Continuous Intravenous Infusion during Parenteral Nutrition in 88 Newborn Infants

Colding¹,

Møller²,

Bentzon³

1983

Dev Pharmacol Ther

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Ampicillin and gentamicin were administered continuously intravenously to 88 newborn infants using individually calculated dosages. For infants with a mean value of plasma clearance of the antibiotics, it was calculated that the serum ampicillin and gentamicin concentrations would be between 35-55 and 3-5 μg/ml, respectively, using the dosages for intermittent treatment. These dosages are therefore recommended as fixed dosages for continuous intravenous infusion initiated by a bolus dosage. Serum gentamicin concentration should be assayed about three half-lives after start of infusion and the dosage adjusted for values outside 3-5 μg/ml.

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Method for the rapid estimation of the total body drug clearance and adjustment of dosage regimens in patients during a constant-rate intravenous infusion

Cited by 64 publications

References 10 publications

Pharmacokinetics of theophylline and its metabolites in rabbits

Pharmacokinetics of theophylline and its metabolites in rabbits

Theophylline Target Concentration in Severe Airways Obstruction - 10 or 20 mg/L?

Kinetics and Dose Calculations of Ampicillin and Gentamicin Given as Continuous Intravenous Infusion during Parenteral Nutrition in 88 Newborn Infants

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