1976
DOI: 10.1007/bf00423282
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Abstract: It has been demonstrated in several diving vertebrates that succinate, a component of the Krebs cycle, accumulates in blood during breath-hold dives. The production of succinate is thought to result from amino acid catabolism. Our purpose was to determine whether succinate accumulation occurs in man during muscular activity requiring anaerobic energy contribution. Experiments using an endurance athlete included apneic work on an underwater ergometer and treadmill running to exhaustion. During 1 min breath-hold… Show more

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Cited by 94 publications
(72 citation statements)
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“…Apparently, anaerobic ATP formation in the myocardium and skeletal muscle plays a certain compensatory role in the adaptation to hypoxia in diving animals (9) and man (8,11) as well as in myocardial ischemia (4,23). An elevation of the plasma concentration of glutamic acid may stimulate anaerobic ATP formation and increase the resistance to severe hypoxia.…”
Section: Discussionmentioning
confidence: 98%
“…Apparently, anaerobic ATP formation in the myocardium and skeletal muscle plays a certain compensatory role in the adaptation to hypoxia in diving animals (9) and man (8,11) as well as in myocardial ischemia (4,23). An elevation of the plasma concentration of glutamic acid may stimulate anaerobic ATP formation and increase the resistance to severe hypoxia.…”
Section: Discussionmentioning
confidence: 98%
“…The concentration of SUC in plasma [57-59] increases with exercise [60], metabolic acidosis [61], hypertension and metabolic diseases [62] from 5 μM up to 125 μM. These data suggest that the tissue concentration of SUC can be high enough to induce astroglial Ca 2+ transients characterised by the EC 50 value for SUC-responsive cells within the range of 50-60 μM.…”
Section: Discussionmentioning
confidence: 99%
“…As such, in situations when oxygen tension is low, succinate accumulates because of low activity of succinate dehydrogenase or other enzymes in the electron transport chain that affect its activity. [5][6][7] Low oxygen states, such as ischemia 8 or exercise 9 also increase circulating levels of succinate. The effect of low oxygen states on succinate levels is also obvious in rats anesthetized with 100% CO 2 instead of oxygenated isoflurane; succinate levels increased from 7 to 40 M in the left ventricle and up to 173 M from lowoxygen blood collected from the vena cava.…”
Section: Regulation Of Succinate Levelsmentioning
confidence: 99%