The Role of Sulfatides in Axon–Glia Interactions

Baba, Hiroko; Ishibashi, Tomoko

doi:10.1007/978-981-32-9636-7_11

Cited by 9 publications

(6 citation statements)

References 91 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In support of such avenues, exogenously applied sulfated RaxX peptide suppresses infection by virulent Xoo strains in rice. 39 Since the term sulfatides is already used for glycolipids, 40 we suggest the term sulfatyrotides for RiPPs where Tyr sulfation is the primary modication.…”

Section: Raxx and Psy1 Sulfatyrotidesmentioning

confidence: 99%

New developments in RiPP discovery, enzymology and engineering

et al. 2021

View full text Add to dashboard Cite

show abstract

Section: Raxx and Psy1 Sulfatyrotidesmentioning

confidence: 99%

New developments in RiPP discovery, enzymology and engineering

et al. 2021

View full text Add to dashboard Cite

show abstract

“…GC is an abundant lipid class located mostly in neuronal tissues (=WM) of animal brains and acting as a structural support for myelin sheets. 55 One can notice that the matrix seems to hide the tissue characteristic peaks on the left side of the cross section that is close to the target. It may suggest that a too thick layer of matrix was deposited on the tissue sample.…”

Section: Mouse Brain Tissue Sectionsmentioning

confidence: 99%

Improvement of Lipid Detection in Mouse Brain and Human Uterine Tissue Sections Using In Situ Matrix Enhanced Secondary Ion Mass Spectrometry

Daphnis,

Tomasetti,

Delmez

et al. 2023

J. Am. Soc. Mass Spectrom.

View full text Add to dashboard Cite

The potential of mass spectrometry imaging, and especially ToF-SIMS 2D and 3D imaging, for submicrometer-scale, label-free molecular localization in biological tissues is undisputable. Nevertheless, sensitivity issues remain, especially when one wants to achieve the best lateral and vertical (nanometerscale) resolution. In this study, the interest of in situ matrix transfer for tissue analysis with cluster ion beams (Bi n + , Ar n +) is explored in detail, using a series of six low molecular weight acidic (MALDI) matrices. After estimating the sensitivity enhancements for phosphatidylcholine (PC), an abundant lipid type present in almost any kind of cell membrane, the most promising matrices were softly transferred in situ on mouse brain and human uterine tissue samples using a 10 keV Ar 3000 + cluster beam. Signal enhancements up to 1 order of magnitude for intact lipid signals were observed in both tissues under Bi 5 + and Ar 3000 + bombardment. The main findings of this study lie in the in-depth characterization of uterine tissue samples, the demonstration that the transferred matrices also improve signal efficiency in the negative ion polarity and that they perform as well when using Bi n + and Ar n + primary ions for analysis and imaging.

show abstract

“…The buildup of these lipids results in improper myelin formation and myelin breakdown in both the CNS and PNS, eventually leading to neuron dysfunction and degeneration. In the PNS, both neurons and Schwann derived lipids are thought to contribute to the pathology (Baba and Ishibashi, 2019). In Schwann cells, sulfatides regulate the initiation of myelin, while in neurons they are instrumental for proper development of nodes of Ranvier (Bosio, Binczek and Stoffel, 2002;Baba and Ishibashi, 2019).…”

Section: Metachromatic Leukodystrophymentioning

confidence: 99%

“…In the PNS, both neurons and Schwann derived lipids are thought to contribute to the pathology (Baba and Ishibashi, 2019). In Schwann cells, sulfatides regulate the initiation of myelin, while in neurons they are instrumental for proper development of nodes of Ranvier (Bosio, Binczek and Stoffel, 2002;Baba and Ishibashi, 2019). Moreover, sulfatide enriched lipid rafts are highly localized to myelin paranodes, highly structured domains adjacent to the nodes of Ranvier (Bonetto and Di Scala, 2019).…”

Section: Metachromatic Leukodystrophymentioning

confidence: 99%

Metabolic Control of Sensory Neuron Survival by the p75 Neurotrophin Receptor in Schwann Cells

et al. 2021

View full text Add to dashboard Cite

2-5, I will detail my own findings, that deletion of the p75 neurotrophin receptor in Schwann cells leads to a significant loss of sensory neurons during development due to the dysregulation of cholesterol biosynthesis and subsequent accumulation of neurotoxic 7-dehydrocholesterol in peripheral nerves. Lastly, Appendix I will describe a separate project investigating the role of NFκB signaling in inherited neuropathy. Appendix II contains supplemental tables, and a bibliography.

show abstract

The Role of Sulfatides in Axon–Glia Interactions

Cited by 9 publications

References 91 publications

New developments in RiPP discovery, enzymology and engineering

New developments in RiPP discovery, enzymology and engineering

Improvement of Lipid Detection in Mouse Brain and Human Uterine Tissue Sections Using In Situ Matrix Enhanced Secondary Ion Mass Spectrometry

Metabolic Control of Sensory Neuron Survival by the p75 Neurotrophin Receptor in Schwann Cells

Contact Info

Product

Resources

About