The Dual Role of Oxidative Stress in Lung Cancer

Ahmed, Abdel Ghaffar M.

doi:10.1007/978-981-13-8413-4_5

Cited by 5 publications

(5 citation statements)

References 91 publications

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“…MMPs are secreted from the tumour cells during metastasis, which leads to extracellular matrix degradation and subsequent invasion of cancer cells to lymph vessels, and blood 39 . Ahmed 40 have reported that the association between oxidative stress and human lung cancer cell survival, proliferation, invasion and metastasis. Scarano et al 41 have reported the increased levels of MMP‐2 and MMP‐9 in final stage of cancer that could be utilized for diagnosing several cancer.…”

Section: Discussionmentioning

confidence: 99%

Naringenin inhibits migration, invasion, induces apoptosis in human lung cancer cells and arrests tumour progression in vitro

Shi¹,

Luo²,

Chen³

et al. 2021

J Cellular Molecular Medi

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Lung cancer is one of the major cause for high‐death rate all over the world, due to increased metastasize and difficulties in diagnosis. Naringenin is naturally occurring flavonoid found in various fruits including tomatoes, citrus fruit and figs. Naringenin is known to have several therapeutic effects including anti‐atherogenic, antimicrobial, anti‐inflammatory, hepatoprotective, anticancer and anti‐mutagenic. The present study was aimed to analyse the naringenin induced anti‐proliferative and apoptosis effects in human lung cancer cells. Cells were treated with various concentrations of naringenin (10, 100 & 200 µmol/L) for 48 hours. Cisplatin (20 µg/mL) was used as positive control. Cell viability, apoptosis, migration and mRNA, and protein expression of caspase‐3, matrixmetallo proteinases‐2 (MMP‐2) and MMP‐9 were determined. The cell viability was 93.7 ± 7.5, 51.4 ± 4.4 and 32.1 ± 2.1 at 10, 100 and 200 µmol/L of naringenin respectively. Naringenin significantly increased apoptotic cells. The 100 and 200 µmol/L of naringenin significantly suppressed the larger wounds of cultured human cancer cells compared with the untreated lung cancer cells. Naringenin increased d the expression of caspase‐3 and reduced the expression of MMP‐2 and MMP‐9. Taking all these data together, it is suggested that the naringenin was effective against human lung cancer proliferation, migration and metastasis.

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Section: Discussionmentioning

confidence: 99%

Naringenin inhibits migration, invasion, induces apoptosis in human lung cancer cells and arrests tumour progression in vitro

Shi¹,

Luo²,

Chen³

et al. 2021

J Cellular Molecular Medi

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“…While labelfree quantitative MS analysis of cell lines suggested that <5% of 20S proteasomes bear PSME4 regulators (Fabre et al, 2014;Morozov and Karpov, 2019), our results suggest that this frequency is increased in many cancer types. As PSME4 is associated with DNA damage and histone organization, we speculate that it may be upregulated to offer a protective mechanism to cope with the associated proteotoxic stress and DNA damage (Ahmed, 2019;Kammerl et al, 2019;M. Cantin and V. Richter, 2012;Srinivas et al, 2019).…”

Section: Discussionmentioning

confidence: 98%

The proteasome regulator PSME4 drives immune evasion and abrogates anti-tumor immunity in NSCLC

Javitt

Shmueli

et al. 2021

Preprint

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Protein degradation by proteasomes is important for the immune response against tumors. Antigens generated by the proteasome promote immune cell infiltration into tumors and improve tumor response to immunotherapy. For example, immunoproteasomes – a subset of proteasomes induced by inflammatory signals – may improve the response of melanomas to immune checkpoint inhibitors (ICI) by eliciting tumor inflammation. Yet, it is unclear whether and how protein degradation by proteasomes impacts cancer progression and contributes to immune evasion and resistance. Here, we profile the proteasome-cleaved peptides in lung cancers and find that PSME4 serves as a novel inhibitory regulator of the immunoproteasome, playing an anti-inflammatory role in cancer. Biochemical assays combined with scRNA-seq, immunopeptidomics and in vivo analyses demonstrate that PSME4 promotes an immunosuppressive environment around the tumor and abrogates anti-tumor immunity by inhibiting antigen presentation and attenuating tumor inflammation. Furthermore, we find that PSME4 expression is correlated with responsiveness to ICI across several cancer types. Our findings suggest that PSME4-mediated regulation of proteasome activity is a novel mechanism of immune evasion in non-small-cell lung carcinoma and may be targeted therapeutically for restoring anti-tumor immunity.

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“…Oxidative stress is another trigger of angiogenesis that linked with aforementioned signaling pathways. Oxidative stress is caused by an imbalance between ROS/RNS production and antioxidants factors, including catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione (GSH) [ 34 ]. Angiogenic inhibitors, including angioarrestin, angiostatin, endostatin, tumstatin, fibronectin fragment, IL-1, IL-12, interferons, canstatin, retinoic acid, arrestin, tissue inhibitors of metalloproteinases (TIMPs), multimerin 2, and angiogenic activators act together to maintain the balance of angiogenesis [ 13 , 19 , 23 , 35 , 36 , 37 ].…”

Section: Angiogenesis: Cellular Signaling Pathwaysmentioning

confidence: 99%

Inhibiting Angiogenesis by Anti-Cancer Saponins: From Phytochemistry to Cellular Signaling Pathways

et al. 2023

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Saponins are one of the broadest classes of high-molecular-weight natural compounds, consisting mainly of a non-polar moiety with 27 to 30 carbons and a polar moiety containing sugars attached to the sapogenin structure. Saponins are found in more than 100 plant families as well as found in marine organisms. Saponins have several therapeutic effects, including their administration in the treatment of various cancers. These compounds also reveal noteworthy anti-angiogenesis effects as one of the critical strategies for inhibiting cancer growth and metastasis. In this study, a comprehensive review is performed on electronic databases, including PubMed, Scopus, ScienceDirect, and ProQuest. Accordingly, the structural characteristics of triterpenoid/steroid saponins and their anti-cancer effects were highlighted, focusing on their anti-angiogenic effects and related mechanisms. Consequently, the anti-angiogenic effects of saponins, inhibiting the expression of genes related to vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1-α (HIF-1α) are two main anti-angiogenic mechanisms of triterpenoid and steroidal saponins. The inhibition of inflammatory signaling pathways that stimulate angiogenesis, such as pro-inflammatory cytokines, mitogen-activated protein kinase (MAPKs), and phosphoinositide 3-kinases/protein kinase B (PI3K/Akt), are other anti-angiogenic mechanisms of saponins. Furthermore, the anti-angiogenic and anti-cancer activity of saponins was closely related to the binding site of the sugar moiety, the type and number of their monosaccharide units, as well as the presence of some functional groups in their aglycone structure. Therefore, saponins are suitable candidates for cancer treatment by inhibiting angiogenesis, for which extensive pre-clinical and comprehensive clinical trial studies are recommended.

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The Dual Role of Oxidative Stress in Lung Cancer

Cited by 5 publications

References 91 publications

Naringenin inhibits migration, invasion, induces apoptosis in human lung cancer cells and arrests tumour progression in vitro

Naringenin inhibits migration, invasion, induces apoptosis in human lung cancer cells and arrests tumour progression in vitro

The proteasome regulator PSME4 drives immune evasion and abrogates anti-tumor immunity in NSCLC

Inhibiting Angiogenesis by Anti-Cancer Saponins: From Phytochemistry to Cellular Signaling Pathways

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