Analgesic, Anti-inflammatory, and Anti-pyretic Activity

Vogel, H. Gerhard

doi:10.1007/978-3-540-70995-4_9

Cited by 20 publications

(25 citation statements)

References 1,149 publications

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“…The relative anti-inflammatory efficacy of the tested preparations and the commercially available reference preparation were measured and compared [ 10 , 15 ]. Male Wistar rats weighing 160–180 g were used in this experiment.…”

Section: Methodsmentioning

confidence: 99%

Serratiopeptidase Niosomal Gel with Potential in Topical Delivery

Shinde

Kanojiya

2014

Journal of Pharmaceutics

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The objective of present study was to develop nonionic surfactant vesicles of proteolytic enzyme serratiopeptidase (SRP) by adapting reverse phase evaporation (REV) technique and to evaluate the viability of SRP niosomal gel in treating the topical inflammation. The feasibility of SRP niosomes by REV method using Span 40 and cholesterol has been successfully demonstrated in this investigation. The entrapment efficiency was found to be influenced by the molar ratio of Span 40 : cholesterol and concentration of SRP in noisome. The developed niosomes were characterized for morphology, particle size, and in vitro release. Niosomal gel was prepared by dispersing xanthan gum into optimized batch of SRP niosomes. Ex vivo permeation and in vivo anti-inflammatory efficacy of gel formulation were evaluated topically. SRP niosomes obtained were round in nanosize range. At Span 40 : cholesterol molar ratio 1 : 1 entrapment efficiency was maximum, that is, 54.82% ± 2.08, and showed consistent release pattern. Furthermore ex vivo skin permeation revealed that there was fourfold increase in a steady state flux when SRP was formulated in niosomes and a significant increase in the permeation of SRP, from SRP niosomal gel containing permeation enhancer. In vivo efficacy studies indicated that SRP niosomal gel had a comparable topical anti-inflammatory activity to that of dicolfenac gel.

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Section: Methodsmentioning

confidence: 99%

Serratiopeptidase Niosomal Gel with Potential in Topical Delivery

Shinde

Kanojiya

2014

Journal of Pharmaceutics

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“…This might be the reason for the macrolides not showing significant analgesic activity. 27 . This may also be the reason for the weak analgesic effect of macrolides.…”

Section: (Ii) Analgesic Evaluationmentioning

confidence: 99%

Analgesic and Anti-inflammatory Activity of Roxithromycin and Erythromycin, Alone and in Combination with Ibuprofen: An Animal Study

Khobragade¹

2011

iosrphr

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Background: Several in-vitro, animal and clinical studies have reported anti-inflammatory activity of macrolides. Antiinflammatory properties of macrolides form the basis for their experimental use in airway inflammatory and infective conditions like asthma Materials and Method: After animal ethics committee approval, the anti-inflammatory and analgesic potentials of erythromycin (40 mg/kg) and roxithromycin (20 mg/kg) were evaluated in carrageenan-induced rat paw edema model and rat tail flick model respectively, in comparison and combination with ibuprofen (100 mg/kg) in albino wistar rats. Results and Interpretation: Both the macrolides were found to have significant anti-inflammatory activity, roxithromycin being slightly more efficacious than erythromycin. Combination with ibuprofen failed to produce improved benefit. Both the macrolides neither showed significant analgesic property alone, nor enhanced analgesic effect of ibuprofen significantly. Conclusion:The macrolides have shown anti-inflammatory activity and a tendency towards analgesic potential; possible mechanisms are discussed. Further studies are required before any recommendations can be made.

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“…The tail-flick test is considered to be selective to examine compounds with central antinociceptive activity, acting through opioid receptors for example (Vogel, 2008). The tail-flick test is considered to be selective to examine compounds with central antinociceptive activity, acting through opioid receptors for example (Vogel, 2008).…”

Section: Discussionmentioning

confidence: 99%

Antihyperalgesic effect of [(±)-(2,4,6-cis)-4-chloro-6-(naphthalen-1-yl)-tetrahydro-2H-pyran-2-yl]methanol: participation of the NO/cGMP/KATP pathway and κ-opioid receptor

Gonçalves

Capim²,

Vasconcellos

et al. 2016

Behavioural Pharmacology

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The present study used behavioral analyses to investigate the involvement of the NO/cGMP/KATP pathway, serotoninergic, and opioid systems in the antinociceptive action of [(±)-(2,4,6-cis)-4-chloro-6-(naphthalen-1-yl)-tetrahydro-2H-pyran-2-yl]methanol (CTHP) in mice. Oral administration of CTHP (1, 5, 10, and 30 mg/kg) exerted effects at higher doses in chemical models of nociception (the acetic acid writhing and formalin tests) as well as a thermal model (the tail-flick test). It was also found that pretreatment with L-N-nitroarginine methyl ester (nonselective nitric oxide synthase inhibitor), 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (selective inhibitor of nitric oxide-sensitive guanosyl cyclase), glibenclamide (selective ATP-sensitive K channel blocker), naloxone (nonselective opioid receptor blocker), and nor-binaltorphimine (selective κ-opioid receptor blocker), but not methylnaltrexone (peripheral μ-opioid receptor blocker) or naltrindole (selective δ-opioid receptor blocker), reversed the antinociceptive effect of CTHP. In addition, CTHP induced the development of tolerance in the tail-flick test: the tolerance appeared later compared with morphine, and was only observed with a higher dose. Taken together, the present study showed that the systemic administration of CTHP reduced pain induced by chemical and thermal stimuli. We also suggest that the possible mechanisms include the involvement of the NO/cGMP/KATP pathway and the κ-opioid receptor.

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Analgesic, Anti-inflammatory, and Anti-pyretic Activity

Cited by 20 publications

References 1,149 publications

Serratiopeptidase Niosomal Gel with Potential in Topical Delivery

Serratiopeptidase Niosomal Gel with Potential in Topical Delivery

Analgesic and Anti-inflammatory Activity of Roxithromycin and Erythromycin, Alone and in Combination with Ibuprofen: An Animal Study

Antihyperalgesic effect of [(±)-(2,4,6-cis)-4-chloro-6-(naphthalen-1-yl)-tetrahydro-2H-pyran-2-yl]methanol: participation of the NO/cGMP/KATP pathway and κ-opioid receptor

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