5-Ht2a Receptors in the Central Nervous System 2018
DOI: 10.1007/978-3-319-70474-6_17
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Cited by 9 publications
(8 citation statements)
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“…Fasting also increases serotonin-induced intracellular calcium cation concentration, a proposed correlate of 5-HT2AR function in the brain ( Sudo et al., 1997 ), as stimulation of 5-HT2ARs induces intracellular calcium release ( Raote et al, 2007 ). Increases in cortical brain-derived neurotrophic factor (BDNF), as well as the antidepressant and anti-inflammatory effects of fasting ( Cui et al., 2018 ; Fond et al, 2013 ), are consistent with the effects of 5-HT2AR activation ( Carhart-Harris et al., 2016a ; Cui et al, 2018 ; Flanagan et al, 2019b ; Jaggar and Vaidya, 2018 ). Acute fasting and intermittent religious fasting have been shown to increase 5-HT levels and metabolism ( Bastani et al, 2017 ; Fuenmayor and Garcia, 1984 ; Ishida et al, 1997 ; although see Bubenik et al, 1992 ) whereas longer-term tryptophan depletion or starvation may decrease 5-HT levels ( Cahir et al, 2007 ; Haider and Haleem, 2000 ).…”
Section: Serotonin Stress and The 5-ht2armentioning
confidence: 70%
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“…Fasting also increases serotonin-induced intracellular calcium cation concentration, a proposed correlate of 5-HT2AR function in the brain ( Sudo et al., 1997 ), as stimulation of 5-HT2ARs induces intracellular calcium release ( Raote et al, 2007 ). Increases in cortical brain-derived neurotrophic factor (BDNF), as well as the antidepressant and anti-inflammatory effects of fasting ( Cui et al., 2018 ; Fond et al, 2013 ), are consistent with the effects of 5-HT2AR activation ( Carhart-Harris et al., 2016a ; Cui et al, 2018 ; Flanagan et al, 2019b ; Jaggar and Vaidya, 2018 ). Acute fasting and intermittent religious fasting have been shown to increase 5-HT levels and metabolism ( Bastani et al, 2017 ; Fuenmayor and Garcia, 1984 ; Ishida et al, 1997 ; although see Bubenik et al, 1992 ) whereas longer-term tryptophan depletion or starvation may decrease 5-HT levels ( Cahir et al, 2007 ; Haider and Haleem, 2000 ).…”
Section: Serotonin Stress and The 5-ht2armentioning
confidence: 70%
“…Consistently, psychedelics have been shown to potently increase cortical neuroplasticity ( Benekareddy et al, 2012 ; Cavus and Duman, 2003 ; Frankel and Cunningham, 2002 ; Gewirtz et al, 2002 ; Jaggar and Vaidya, 2018 ; Jones et al, 2009 ; Meller et al, 2002 ; Niitsu et al, 1995 ; Vaidya et al, 1997 ). A doubling of BDNF mRNA was found in the parietal cortex after administration of the 5-HT2AR agonist DOI ( Vaidya et al, 1997 ) and markedly increased functional and structural neuroplasticity has been found after DMT, LSD and 2,5-Dimethoxy-4-iodamphetamine (DOI) ( Ly et al, 2018 ) – leading the senior author to introduce the term ‘psychoplastogen’ for these and any other relevant compounds that can rapidly elicit appreciable increases in neuroplasticity ( Olson, 2018 ).…”
Section: Psychedelics Pivotal Mental States and The 5-ht2armentioning
confidence: 91%
“…, 1997 ; Musazzi et al. , 2014 ; Jaggar and Vaidya, 2018 ). DOI increases expression of mRNA for the neuroplasticity-associated protein Arc ( Korb and Finkbeiner, 2011 ) via a pathway that depends on glutamate and BDNF signaling ( Pei et al.…”
Section: Neural and Behavioral Plasticitymentioning
confidence: 99%
“…On the other hand, hippocampus is less sensitive to MDMA, as only its chronic application increases BDNF levels (Abad et al, 2014; Mouri et al, 2017), while, conversely, acute MDMA can produce a significant decrease in BDNF mRNA expression (Martinez‐Turrillas et al, 2006). Considering the strong crosstalk between 5‐HT 2A receptors and BDNF in response to hallucinogens (Benekareddy et al, 2013), the increase in BDNF expression across the FE circuitry likely occurs in a 5‐HT 2A ‐dependent manner (Jaggar & Vaidya, 2018; Vaidya et al, 1997), supporting the notion that 5‐HT 2A receptors are necessary for MDMA's effects on fear‐related memory processing. This is further substantiated by evidence that the use of a selective 5‐HT 2A antagonist in a paradigm of FE blocked MDMA's facilitatory effect on extinction learning (Young et al, 2017).…”
Section: Hallucinogenic Drugsmentioning
confidence: 86%