Nanomaterials Used for Delivery of Bioactives

Jain, Akhlesh Kumar; Gupta, Umesh

doi:10.1007/978-3-030-34544-0_19

Cited by 1 publication

(1 citation statement)

References 77 publications

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“…In nanoparticles based on solid lipids, there is a core of such lipids as octadecylamine, dioleolyl-3-trimethylammonium propane, and dioleolylphosphatidylethanolamine, which is stabilized by surfactants in an aqueous suspension. The mobility of the drug being delivered in such particles is appreciably reduced, and its release can be more con-trolled [120]. Solid lipid-based nanoparticles share their low toxicity with liquid lipid-based particles, but at the same time, have a number of advantages, specifically, they appear promising vehicles for the delivery of macromolecules.…”

Section: Lipid-based Nanoparticlesmentioning

confidence: 99%

Application Prospects for Synthetic Nanoparticles in Optogenetic Retinal Prosthetics

Rotov

Romanov

Tarakanchikova

2021

J Evol Biochem Phys

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Optogenetic prosthetics is an approach to restore visual function in retinal degenerative diseases. It implies the delivery of genes encoding light-sensitive proteins to retinal cells that survived degeneration, primarily bipolar and ganglion cells. As a result, these cells turn into "pseudophotoreceptors" which are able to take on the function of rods and cones lost in disease. The key element of the optogenetic prosthetic procedure is a vector that delivers exogenous DNA to the nucleus of a retinal cell. There are two main categories of vectors: viral and synthetic. The latter include nanoparticles derived from various polymers, lipids and inert metals. Previously, it was believed that viruses transfect living cells more efficiently than their synthetic counterparts due to the presence of specialized gene delivery mechanisms. However, to date, there have been developed nanoparticles that can effectively penetrate through tissue barriers, get into the cell, and successfully deliver nucleic acid molecules to the nucleus. This review addresses the current approaches to the development of nanocarriers and defines the major requirements for their physicochemical properties to ensure most efficient transfer of the genetic material across the intraocular barriers and its delivery to bipolar and ganglion cells. Based on the literature data, several types of nanoparticles have been selected that appear most promising in terms of optogenetic retinal prosthetics.

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Section: Lipid-based Nanoparticlesmentioning

confidence: 99%