Microreactor Technology as an Efficient Tool for Multicomponent Reactions

The integration of flow reactors into synthetic organic chemistry

“…This therefore becomes particularly important when considering process development routes and scaled manufacture where cryogenic temperatures also become expensive and challenging engineering problems. It has therefore been of significant general interest to the chemical community that as a consequence of their high surface to volume ratios many microreactor systems display excellent heat transfer charactoristics . This often means a greater stability in reaction temperature especially when mixing reactive reagents.…”

Efficient one pot multi-component domino Aldol condensation–Michael addition–Suzuki coupling reaction for the highly functionalized quinolines

“…It is noteworthy that when water was added to ethanol, the desired product 4a was obtained with an increased yield to 45% at 6h (entry 10). In the like manner, with the reaction improved condition, the catalyst loading and base variation were explored (entries [10][11][12][13][14][15][16]. Accordingly, among the tested bases, for instance, Na 2 CO 3 , NaOH, TEA, K 2 HPO 4 , Cs 2 CO 3 and K 3 PO 4 , NaOH and K 2 HPO 4 gave 80 and 82 % (entries 13 and 14), while K 3 PO 4 gave excellent yield of 92% (entry 16) while Cs 2 CO 3 , Na 2 CO 3 gave poor yields.…”

“…The parallel reactions are helpful to minimize the cost reasonably and could be done under same reaction conditions (Scheme 1, Eq. 1-5) without isolating the reaction intermediates [7][8][9][10][11][12][13][14][15][16][17][18][19][20] . The expense and mass production conditions of this strategy could be handled through parallel robotized syntheses and by precise investigation of the chemical reactions.…”

Optimization for speed and sensitivity in capillary high performance liquid chromatography. The importance of column diameter in online monitoring of serotonin by microdialysis

“…There are many important examples of flowing streams that are sampled periodically for analysis, for example microdialysis[1–3], microreactors[4–9], and even a chromatographic effluent as a first stage in a two- or three-dimensional separation[10–12]. When analysis of a flowing stream requires taking samples from the flowing stream, the sample volume is a key parameter in defining the attributes of the system.…”