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Cited by 30 publications
(28 citation statements)
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“…Regulation of normal and breast cancer cell proliferation by ECM proteins has also been reported 30 (Pourreau-Schneider et al, 1984;Elliott et al, 1992;Xie and Haslam, 1997 This enhanced response to estrogen may have been mediated by secreted ECM proteins, however, since other mammary carcinoma cell lines have been reported to increase secretion of FN when cultured as spheroid colonies in suspension (Saulnier et al, 1996). The present study is the first to demonstrate regulation of estrogen regulated events in breast cancer cells by specific purified extracellular matrix proteins in serum-free conditions.…”
Section: Integrin Alpha 6 Studies (Studies Added In Annual Report Yeasupporting
confidence: 73%
“…Regulation of normal and breast cancer cell proliferation by ECM proteins has also been reported 30 (Pourreau-Schneider et al, 1984;Elliott et al, 1992;Xie and Haslam, 1997 This enhanced response to estrogen may have been mediated by secreted ECM proteins, however, since other mammary carcinoma cell lines have been reported to increase secretion of FN when cultured as spheroid colonies in suspension (Saulnier et al, 1996). The present study is the first to demonstrate regulation of estrogen regulated events in breast cancer cells by specific purified extracellular matrix proteins in serum-free conditions.…”
Section: Integrin Alpha 6 Studies (Studies Added In Annual Report Yeasupporting
confidence: 73%
“…This suggests that a5b1 plays no important role in polarized epithelial cells tightly adhering to a basement membrane. Rather, integrins like a5b1 become expressed in certain 'emergency' situations, such as wounding or tumor development, during which basement membranes are destroyed and epithelial cells have to survive and migrate within or in close contact to a stromal environment (Saulnier et al, 1996). Basement membrane disruption, per se, induces TGFb1 expression (Streuli et al, 1993) leading to increased production of ECM proteins, reformation of the basement membrane and downregulation of TGFb1 synthesis.…”
Section: Discussionmentioning
confidence: 99%
“…Evidence also exists, however, that FN can stimulate growth of melanoma cell lines and primary and metastatic melanomas in a ␣5␤1-integrin-dependent manner (Mortarini et al, 1992) and that blocking antibodies to ␣5␤1-integrin inhibits the in vivo growth of human bronchial epithelial tumor cells (Schiller and Bittner, 1995). Also, anchorage-independent growth in soft agar of a murine mammary carcinoma cell line was shown to be dependent on the presence of FN fibrils within the colonies (Saulnier et al, 1996). Such diverse findings do not allow the results from one model to be safely extrapolated to other cells.…”
Section: Mapkmentioning
confidence: 98%