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Cited by 381 publications
(314 citation statements)
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“…Indeed hypoxia exposure whether, in vitro or in vivo, is associated with rise in inflammatory markers. However, in the previous studies, as also quoted in the article by the authors, the duration of hypoxia exposure varied from 16 to 72 h [2][3][4][5] On the contrary, in the present study duration of simulated hypoxia of 4500 m was only 30 min. It remains obscure that those changes seen in the chemokines are actually the result of hypoxia induced inflammation or otherwise.…”
Section: To the Editorcontrasting
confidence: 51%
“…Indeed hypoxia exposure whether, in vitro or in vivo, is associated with rise in inflammatory markers. However, in the previous studies, as also quoted in the article by the authors, the duration of hypoxia exposure varied from 16 to 72 h [2][3][4][5] On the contrary, in the present study duration of simulated hypoxia of 4500 m was only 30 min. It remains obscure that those changes seen in the chemokines are actually the result of hypoxia induced inflammation or otherwise.…”
Section: To the Editorcontrasting
confidence: 51%
“…IL6 secretion has been demonstrated to be facilitated by hypoxia in human umbilical vein and pulmonary endothelial cells, primary human pulmonary fibroblasts and vascular smooth muscle cells, and Kupffer cells as well as whole pulmonary artery organoid cultures (Yan et al, 1995(Yan et al, , 1997Tamm et al, 1998;Ziesche et al, 1996;Kotake-Nara et al, 2005;Sawa et al, 1998;Hartmann et al, 2000). Our previous studies found that the level of IL-6 was increased in pulmonary tissues of rats with hypoxia-induced pulmonary hypertension .…”
Section: Discussionmentioning
confidence: 95%
“…A number of studies have demonstrated that secretion of interleukins is facilitated by hypoxia (Yan et al, 1995(Yan et al, , 1997Tamm et al, 1998;Ziesche et al, 1996;Kotake-Nara et al, 2005;Sawa et al, 1998;Hartmann et al, 2000). Several studies have also indicated that Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) are activated by interleukin 6 (IL6) in cardiomyocytes, macrophages, carcinoma cells and neurons and by hypoxia in pulmonary arterial smooth muscle cells, rat cardiomyocytes, retinal microvascular endothelial cells (Negoro et al, 2001;Mascareno et al, 2005;Wang et al, 2005;Dawn et al, 2004;Lee et al, 2006;Yamauchi et al, 2006;Terrell et al, 2006).…”
Section: Introductionmentioning
confidence: 99%
“…Sabe-se que a hipoxemia da alta atitude e a privação do sono provocam aumento de IL6 e PCR em indivíduos normais (27). Portanto, nos pacientes com SAOS, a hipoxemia que ocorre repetidamente durante o sono, acompanhada da privação do sono, pode induzir a um estado sistêmico inflamatório, evidenciado pela elevação de PCR, amiloide A, IL-6 e TNF-α (9,28).…”
Section: Interações Entre Apnéia Do Sono E Resistência à Insulinaunclassified