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Cited by 91 publications
(61 citation statements)
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“…Cellular macromolecules including DNA are very susceptible to oxidative injury by ROS, [58]. Other studies indicate that ROS can affect the functional as well as structural integrity of cell membrane and organelles [59] But according to Hickey et al [38] DCLF suppress cellular genomic repair capability, and activated kidney endonuclease to produce damage.…”
Section: Discussionmentioning
confidence: 99%
“…Cellular macromolecules including DNA are very susceptible to oxidative injury by ROS, [58]. Other studies indicate that ROS can affect the functional as well as structural integrity of cell membrane and organelles [59] But according to Hickey et al [38] DCLF suppress cellular genomic repair capability, and activated kidney endonuclease to produce damage.…”
Section: Discussionmentioning
confidence: 99%
“…Grape seed extracts protect heart function and reduce infarct size in experimental cardiac ischemia (Shao et al, 2003). It prevents acetaminophen-induced liver damage (Ray et al, 1999) and puromycin-induced nephrosis (Mattoo and Kovacevic, 2003). In a previous study, the protective effects were demonstrated of GSE against bile duct ligation-induced hepatic fibrosis where oxidative stress takes place (Dulundu et al, 2007).…”
Section: Introductionmentioning
confidence: 98%
“…Oxidative stress due to paracetamol intoxication involves membrane perturbation via NAPQI (N-acetyl-p-benzoquinone imine) binding to parenchyma cell proteins (forming protein adducts which are responsible for the dysfunction and death of hepatocytes, leading to liver necrosis) and is mediated by lipid modification, inhibition of transcription, translation and fragmentation of DNA (Vermeulen et al, 1992;Ray et al, 1999). The acute toxicity evaluation showed neither toxicity nor mortality even at a dose of 6000 mg V. calvaona extract/kg b.wt of animal.…”
Section: Discussionmentioning
confidence: 99%
“…The administration of paracetamol is safe when therapeutic dose is not exceeded, however, it can cause hepatic necrosis, nephrotoxicity, extra-hepatic lesions and even death in humans and experimental animals when taken in overdose (Ray et al, 1999;Webster et al, 1996;Mohanraj et al, 2013). Acetaminophen -induced renotoxicity at 750 mg/kg body weight had been established by Sathishkumar and Baskar (2014).…”
Section: Introductionmentioning
confidence: 99%