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Cited by 67 publications
(48 citation statements)
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References 22 publications
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“…Indeed, the enzymatic hydrolysis of anandamide by FAAH is blocked by ibuprofen, ketorolac and flurbiprofen (Fowler et al, 1997(Fowler et al, , 1999) so that anandamide is not degraded, and thus, present locally in greater amounts to decrease pain behaviour. We have shown in a previous study that the combination of anandamide with ibuprofen produced synergistic antinociceptive effects but the mechanism of this interaction, although mediated in part by cannabinoid CB 1 and CB 2 receptors, was not clear (Guindon et al, 2006).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Indeed, the enzymatic hydrolysis of anandamide by FAAH is blocked by ibuprofen, ketorolac and flurbiprofen (Fowler et al, 1997(Fowler et al, , 1999) so that anandamide is not degraded, and thus, present locally in greater amounts to decrease pain behaviour. We have shown in a previous study that the combination of anandamide with ibuprofen produced synergistic antinociceptive effects but the mechanism of this interaction, although mediated in part by cannabinoid CB 1 and CB 2 receptors, was not clear (Guindon et al, 2006).…”
Section: Discussionmentioning
confidence: 99%
“…However, other mechanisms have been proposed, such as interactions with endocannabinoids (Fowler et al, 1997). Indeed, FAAH activity, responsible for the degradation of anandamide, is inhibited by NSAIDs such as ibuprofen, ketorolac and flurbiprofen (Fowler et al, 1997(Fowler et al, , 1999. However, very little information is available in the literature on the antinociceptive effects of the combination of a cannabinoid with an NSAID.…”
Section: Introductionmentioning
confidence: 99%
“…Bishay et al (2010) found that systemically administered (R)-flurbiprofen alleviated mechanical hyperalgesia, cold allodynia and cold hyperalgesia in the spared nerve injury model of neuropathic pain accompanied by a normalisation of AEA levels in the dorsal root ganglia, dorsal horn and forebrain. (R)-flurbiprofen inhibits FAAH (Fowler et al 1999), but a key mechanism of action is its ability to block the oxygenation of eCBs at lower concentrations than are required for inhibition of arachidonic acid (Duggan et al 2011). This is also the case for an analogue of indomethacin, LM-4131, which increases brain AEA and to a lesser extent 2-AG concentrations.…”
Section: Oxygenating Enzymes (Cox-2)mentioning
confidence: 91%
“…La démonstration la plus pertinente actuellement, même si elle n'est pas, de notre point de vue, absolue, est celle de l'inhibition des effets antalgiques des AINS, administrés par voie intrathécale, par des antagonistes des récepteurs CB1, eux-mêmes injectés par voie centrale [2,21,32,68]. Il a, enfin, été montré que l'ibuprofène, le kétorolac et le flurbiprofène étaient capables d'inhiber la FAAH, enzyme qui permet la dégradation de l'anandamide [26,27,33].…”
Section: Un Mécanisme Faisant Intervenir Les Endocannabinoïdesunclassified