2012
DOI: 10.1002/mabi.201100367
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Abstract: A novel amphiphilic and biodegradable polyelectrolyte DS-CA is prepared by the esterification of DS with CA. DS-CA can self-assemble into stable nanoparticles in water. SOD can effectively associate with DS-CA at pH = 5.0 by virtue of electrostatic and hydrophobic interactions. SOD release from the complex nanoparticles is slow at pH = 1.2. The release at pH = 7.4 PBS shows an extended behavior and is tunable by changing the weight ratio of SOD to DS-CA as well as the CA substitution degree. Increasing the CA … Show more

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Cited by 19 publications
(12 citation statements)
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“…Presumably, the encapsulation of CyA enhances the hydrophobic interactions in the core and produces more compact particles. In vitro studies showed HPC-PEO-C 16 micellar system had high affinity to mucus and could enhance the permeability of entrapped therapeutics across intestine epithelial-Caco-2 cells [ 60 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 ]. These studies demonstrated the great potential of HPC-based micelles for improved oral delivery of hydrophobic molecules.…”
Section: Polysaccharide-based Micelle Drug Delivery Systemsmentioning
confidence: 99%
See 1 more Smart Citation
“…Presumably, the encapsulation of CyA enhances the hydrophobic interactions in the core and produces more compact particles. In vitro studies showed HPC-PEO-C 16 micellar system had high affinity to mucus and could enhance the permeability of entrapped therapeutics across intestine epithelial-Caco-2 cells [ 60 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 ]. These studies demonstrated the great potential of HPC-based micelles for improved oral delivery of hydrophobic molecules.…”
Section: Polysaccharide-based Micelle Drug Delivery Systemsmentioning
confidence: 99%
“…More recently, dextran sulfate-cholic acid was investigated to deliver superoxide dismutase (SOD) orally. SOD-loaded dextran sulfate-cholic acid had a high stability against the acidic environment of the stomach and release in the small intestine was controlled up to 100 h. Moreover, dextran sulfate-cholic acid facilitated SOD cellular uptake, suggesting that cholic acid enhanced the interaction of micelles with the intestinal membrane [ 60 ]. Additional dextran-based micelles have been synthesized by grafting of polycaprolactone [ 95 ], poly (L-lactide) [ 55 ], polystyrene [ 126 ], lauryl group [ 127 ], and methyl methacrylate-ethylene glycol dimethacrylate [ 128 ] to the dextran backbone.…”
Section: Polysaccharide-based Micelle Drug Delivery Systemsmentioning
confidence: 99%
“…Hydroxypropyl cellulose was prepared by modifying the cellulose hydroxyl groups with propylene oxide to enhance cellulose solubility and control drug release [17]. Superoxide dismutase-loaded dextran sulfate-cholic acid micelles showed higher stability in acidic medium and sustained drug release up to 100 h in the small intestine, which enhanced the interaction of copolymer micelles with the intestinal membrane and facilitated superoxide dismutase cellular uptake [18]. Stearic acid (SA)-modified chitosan drug-loaded micelles showed significantly higher tumor cell inhibition in vitro compared with free drugs, enhancing drug internalization [19].…”
Section: Introductionmentioning
confidence: 99%
“…BAs can be also introduced as pendant groups in block copolymers and thereby used to tune their properties and functionalities such as pH-and thermo-responsiveness and self-healing properties (Figure 4c,d) [119,120]. The investigation of the aggregates formed by these macromolecules has been promoted for their potential in drug and gene delivery applications [119,[121][122][123].…”
Section: Ba-based Polymersmentioning
confidence: 99%