1985
DOI: 10.1002/jez.1402340205
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Abstract: Treatment of the killifish, Fundulus heteroclitus, with ovine thyrotropin (oTSH) produced elevations in serum thyroxin (T4) that varied seasonally with a strong inverse correlation to environmental photoperiod (P less than 0.001). At 20 degrees C, oTSH (0.2 IU) increased serum T4 to levels ranging from 1.5 micrograms/100 ml in midsummer to 7.5 micrograms/100 ml in midwinter despite relatively stable resting levels throughout the two years of study. Similar rates of clearance of T4 in summer and winter suggest … Show more

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Cited by 21 publications
(8 citation statements)
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“…The response of thyroid tissue to a standa~'xtized TSH dose is not fixed for a given species, but varies with season and physiologic state (Milne and Leatherland, 1980;Grau et al, 1985;Specker and Richman, 1984;Specker and Schreck, 1984;Specker and Kobuke, 1987;Swanson and Dickhoff, 1987). For the killifish (Fundulus heteroclitus, Cyprinodontidae), the seasonal differences in the TSH-induced plasma T4 level were not explained by any alterations in plasma T4 clearance, supporting the view that the seasonal changes in TSH action probably occurred at the level of the thyroid tissue itself (Grau et al, 1985).…”
Section: Pituitary-thyroid Controlsupporting
confidence: 52%
See 1 more Smart Citation
“…The response of thyroid tissue to a standa~'xtized TSH dose is not fixed for a given species, but varies with season and physiologic state (Milne and Leatherland, 1980;Grau et al, 1985;Specker and Richman, 1984;Specker and Schreck, 1984;Specker and Kobuke, 1987;Swanson and Dickhoff, 1987). For the killifish (Fundulus heteroclitus, Cyprinodontidae), the seasonal differences in the TSH-induced plasma T4 level were not explained by any alterations in plasma T4 clearance, supporting the view that the seasonal changes in TSH action probably occurred at the level of the thyroid tissue itself (Grau et al, 1985).…”
Section: Pituitary-thyroid Controlsupporting
confidence: 52%
“…For the killifish (Fundulus heteroclitus, Cyprinodontidae), the seasonal differences in the TSH-induced plasma T4 level were not explained by any alterations in plasma T4 clearance, supporting the view that the seasonal changes in TSH action probably occurred at the level of the thyroid tissue itself (Grau et al, 1985). Photoperiod, temperature, and salinity may in some instances modify teleost thyroidal sensitivity to TSH and TSH efficacy in the control of thyroid function (Olivereau, 1955;Delso and Flatin, 1956;Fontaine and Fontaine 1957;Lysak 1971a,b;Chart and Eales, 1976;Milne and Leatherland, 1980;Specker and Richman, 1984;Grau et al, 1985;Eales and Himick, 1991).…”
Section: Pituitary-thyroid Controlmentioning
confidence: 53%
“…In these taxa at least, short day-lengths may decrease the sensitivity of the hypothalamic-hypophyseal negative feedback mechanism, thereby enabling prolonged thyroidal responses to the thyroid-stimulating hormone Grau et al, 1985). Strong field correlations in the present study support such a thyroid responsiveness model: the night-length was correlated positively and simultaneously with the thyroid follicular cell height (r 2 =0·92) (data taken from Woodhead, 1959) and the major thyroid secretion (T 4 ) (r 2 =0·59).…”
Section: Description Of Thyroid Cyclesmentioning
confidence: 99%
“…In the present study, different responses of plasma TSH level was observed upon exposure to various concentrations of CA (decreased at maximum level) and DCF (increased at maximum level) during short and long-term treatments. An increased level of TSH has been reported in fish Liza aurata collected from contaminated sites of Ria de Aveiro, Portugal (Oliveira et al, 2011), zebra fish (Danio rerio) exposed to triadimefon (Liu et al, 2011) and perchlorate (Patino et al, 2003) and in Fundulus heteroclitus exposed to melatonin (Grau et al, 1985). TSH increase would be expected upon a plasma T 4 decrease and/or lower level of TH production by the pituitary (Patino et al, 2003;Teles et al, 2005;Oliveira et al, 2011).…”
Section: Discussionmentioning
confidence: 95%
“…Maclatchy and Eales (1990) suggest that an increase in T 4 level could be a consequence of the decreased GH levels. In addition, the increased level of T 4 might be either due to increase in TSH secretion or sensitivity of thyroid follicles to TSH (Grau et al, 1985) or may be due to inhibition of 5 -deiodinase (responsible for accelerating peripheral deiodination of T 4 to T 3 in plasma) (Gupta and Premabati, 2002). Increase in T 4 may be explained as increased TSH (TSH-beta) (Liu et al, 2011).…”
Section: Discussionmentioning
confidence: 97%