2009
DOI: 10.1002/etc.34
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Abstract: Ecological risk assessors face increasing demands to assess more chemicals, with greater speed and accuracy, and to do so using fewer resources and experimental animals. New approaches in biological and computational sciences may be able to generate mechanistic information that could help in meeting these challenges. However, to use mechanistic data to support chemical assessments, there is a need for effective translation of this information into endpoints meaningful to ecological risk-effects on survival, de… Show more

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Cited by 2,050 publications
(1,155 citation statements)
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References 63 publications
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“…Thus, they can alert on specific hazardous potentials of chemicals, and they can assist in grouping chemicals according to their modes of action (Diamond et al 2011;Segner 2011). With the adverse outcome pathway (AOP) concept suggested by Ankley et al (2010)), a framework is available which links data collected from lower levels of biological organization through the use of, e.g. highthroughput screening, toxicogenomic assays, in vitro cellular assays or histopathological assessments to higher levels of biological organization, although it must not be overlooked that the effect propagation is neither deterministic nor always linear (Ankley et al 2010); Segner 2011).…”
Section: This Special Issue Of Environmental Science and Pollutionmentioning
confidence: 99%
“…Thus, they can alert on specific hazardous potentials of chemicals, and they can assist in grouping chemicals according to their modes of action (Diamond et al 2011;Segner 2011). With the adverse outcome pathway (AOP) concept suggested by Ankley et al (2010)), a framework is available which links data collected from lower levels of biological organization through the use of, e.g. highthroughput screening, toxicogenomic assays, in vitro cellular assays or histopathological assessments to higher levels of biological organization, although it must not be overlooked that the effect propagation is neither deterministic nor always linear (Ankley et al 2010); Segner 2011).…”
Section: This Special Issue Of Environmental Science and Pollutionmentioning
confidence: 99%
“…[3] A critical element of this cluster is its focus on repeated dose toxicity and the adoption of a mode-of-action (MOA) framework based on an understanding of key biological events driven by levels of exposure over time. [4][5][6][7][8] The SEURAT-1 cluster is comprised of five complementary research projects (COSMOS, [9,10] DETECTIVE, [11,12] HeMiBio, [13][14] NOTOX, [15][16][17] Abstract: The aim of the SEURAT-1 (Safety Evaluation Ultimately Replacing Animal Testing-1) research cluster, comprised of seven EU FP7 Health projects co-financed by Cosmetics Europe, is to generate a proof-of-concept to show how the latest technologies, systems toxicology and toxicogenomics can be combined to deliver a test replacement for repeated dose systemic toxicity testing on animals. The SEURAT-1 strategy is to adopt a mode-of-action framework to describe repeated dose toxicity, combining in vitro and in silico methods to derive predictions of in vivo toxicity responses.…”
Section: The Seurat-1 Clustermentioning
confidence: 99%
“…Multidisciplinary perspectives and techniques, for example from genetics, physiology, and ecology, have yielded a robust understanding of toxicological outcomes and mechanisms across levels of biological organization, from molecular processes to population‐level and community‐level consequences (Peterson et al., 2003; Sturla et al., 2014; Whitehead, Pilcher, Champlin, & Nacci, 2012). Indeed, efforts aimed at understanding how molecular impacts of contaminants shape ecological outcomes have become a recent focus of ecotoxicology (e.g., “adverse outcome pathways,” Ankley et al., 2010). …”
Section: Introductionmentioning
confidence: 99%