The aim of the SEURATâ1 (Safety Evaluation Ultimately Replacing Animal Testingâ1) research cluster, comprised of seven EU FP7 Health projects coâfinanced by Cosmetics Europe, is to generate a proofâofâconcept to show how the latest technologies, systems toxicology and toxicogenomics can be combined to deliver a test replacement for repeated dose systemic toxicity testing on animals. The SEURATâ1 strategy is to adopt a modeâofâaction framework to describe repeated dose toxicity, combining in vitro and in silico methods to derive predictions of in vivo toxicity responses. ToxBank is the crossâcluster infrastructure project whose activities include the development of a data warehouse to provide a webâaccessible shared repository of research data and protocols, a physical compounds repository, reference or âgold compoundsâ for use across the cluster (available via wiki.toxbank.net), and a reference resource for biomaterials. Core technologies used in the data warehouse include the ISAâTab universal data exchange format, REpresentational State Transfer (REST) web services, the W3C Resource Description Framework (RDF) and the OpenTox standards. We describe the design of the data warehouse based on cluster requirements, the implementation based on open standards, and finally the underlying concepts and initial results of a data analysis utilizing public data related to the gold compounds.