2004
DOI: 10.1002/elan.200302915
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Abstract: Single-wall carbon nanotubes (SWNTs) can be used as an electrochemical probe to study the electrochemical oxidation of DNA, two voltammetric oxidation peaks corresponding to electrochemical oxidation of guanine and adenine residues in DNA could be observed, demonstrating a new potential application of SWNTs in DNA analysis. Compared to other types of electrode materials, the electrochemical response of natural DNA was greatly enhanced at the SWNT-modified electrode. This method can be used to investigate the i… Show more

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Cited by 126 publications
(56 citation statements)
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References 33 publications
(21 reference statements)
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“…current, potential, conductance, impedance, capacitance). Again, the use of CNTs in electrochemical DNA biosensors is quite promising for the reasons given before: CNTs constitute novel platforms for DNA immobilization with important electrochemical transducing properties and high specific surface area which can increase not only the attached DNA amount but also concentrate a great number of enzymes or electroactive nanoparticles to amplify DNA hybridization (Wang, 2003;Wang, 2004;Wang, 2004a;Wang, 2005;He, 2006;Kim, 2007,). For instance it has been observed in some studies an enhanced guanine signal which was attributed to a CNT-induced interfacial accumulation of the analyte (due to its large surface area/volume ratio).…”
Section: Genosensorsmentioning
confidence: 99%
See 2 more Smart Citations
“…current, potential, conductance, impedance, capacitance). Again, the use of CNTs in electrochemical DNA biosensors is quite promising for the reasons given before: CNTs constitute novel platforms for DNA immobilization with important electrochemical transducing properties and high specific surface area which can increase not only the attached DNA amount but also concentrate a great number of enzymes or electroactive nanoparticles to amplify DNA hybridization (Wang, 2003;Wang, 2004;Wang, 2004a;Wang, 2005;He, 2006;Kim, 2007,). For instance it has been observed in some studies an enhanced guanine signal which was attributed to a CNT-induced interfacial accumulation of the analyte (due to its large surface area/volume ratio).…”
Section: Genosensorsmentioning
confidence: 99%
“…Such orientation of the adsorbed DNA and the reduced flexibility of the adsorbed DNA can decrease the efficiency of the hybridization event. Albeit the direct oxidation does not need the additional use of redox labellings, the process itself also presents the difficulties of the high oxidation potentials at which significant background currents are present (Wang, 2003;Wang, 2004). Among the DNA bases, guanine is the one which exhibits the lower electrochemical overpotential for oxidation, though still remains relative high (close to 1 V).…”
Section: Genosensorsmentioning
confidence: 99%
See 1 more Smart Citation
“…Adenine and guanine residues of DNA can electrochemically be detected with a poor signal and a low sensitivity at various electrodes such as gold, glassy carbon (GC), carbon nanotubes (CNTs), and polymer modified graphite/GC [78][79][80][81][82][83]. From a fundamental point of view, the main problem on evaluating the use of CNTs for electrochemical applications such as sensors and energy storage devices, is the presence of metallic impurities, as the synthesis of nanotubes is usually achieved with the use of metal catalyst.…”
Section: Biosensingmentioning
confidence: 99%
“…Recent studies have demonstrated that CNTs exhibits strong electrocatalytic activity for a wide range of compounds, such as neurotransmitters [20,21] NADH [22], hydrogen peroxide [23], ascorbic [24,25], cytochrome c [26], hydrazines [27], hydrogen sulphide [28], amino acids [29], glucose [30] and DNA [31]. It has been suggested that electrocatalytic properties originate from the ends of CNTs [32].…”
mentioning
confidence: 99%