Notch and Bmp signaling pathways act coordinately during the formation of the proepicardium

Andrés-Delgado, Laura; Galardi-Castilla, María; Münch, Juliane; Peralta, Marina; Ernst, Alexander; González‐Rosa, Juan Manuel; Tessadori, Federico; Santamarı́a, Luis; Bakkers, Jeroen; Vermot, Julien; Pompa, José Luis de la; Mercader, Nadia

doi:10.1002/dvdy.229

Cited by 8 publications

(4 citation statements)

References 62 publications

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“…Utilizing zebrafish as a model and combining transgenic reporters, via CRISPR/Cas9, different studies have performed functional testing of candidate genes associated with CHD. The results obtained showed that genes encoding transcription factors, such as GATA4/5/6 [ 100 , 101 ], NKX2.5 [ 102 ], and HAND2 [ 103 , 104 ], or cell signaling molecules, such as NOTCH1 [ 105 , 106 ] and SMAD6 [ 107 , 108 ] cause CHD in humans and play an important role for heart development in zebrafish. In addition, genes associated with cardiomyocyte function, which cause CHD in zebrafish include MYH6 [ 109 ], ACTC [ 110 ], TITIN [ 111 ], and KCNH2 [ 112 ].…”

Section: Zebrafish To Study Human Cardiac and Vessel Alterationsmentioning

confidence: 99%

Zebrafish as a Model of Cardiac Pathology and Toxicity: Spotlight on Uremic Toxins

Coppola

Lombari

Mazzella

et al. 2023

IJMS

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Chronic kidney disease (CKD) is an increasing health care problem. About 10% of the general population is affected by CKD, representing the sixth cause of death in the world. Cardiovascular events are the main mortality cause in CKD, with a cardiovascular risk 10 times higher in these patients than the rate observed in healthy subjects. The gradual decline of the kidney leads to the accumulation of uremic solutes with a negative effect on every organ, especially on the cardiovascular system. Mammalian models, sharing structural and functional similarities with humans, have been widely used to study cardiovascular disease mechanisms and test new therapies, but many of them are rather expensive and difficult to manipulate. Over the last few decades, zebrafish has become a powerful non-mammalian model to study alterations associated with human disease. The high conservation of gene function, low cost, small size, rapid growth, and easiness of genetic manipulation are just some of the features of this experimental model. More specifically, embryonic cardiac development and physiological responses to exposure to numerous toxin substances are similar to those observed in mammals, making zebrafish an ideal model to study cardiac development, toxicity, and cardiovascular disease.

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Section: Zebrafish To Study Human Cardiac and Vessel Alterationsmentioning

confidence: 99%

Zebrafish as a Model of Cardiac Pathology and Toxicity: Spotlight on Uremic Toxins

Coppola

Lombari

Mazzella

et al. 2023

IJMS

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“…Furthermore, the BMP signaling promotes the development of endocardial cells (ECs) from hPSC-derived cardiovascular progenitors[ 23 ]. It is also integrated with Notch signaling for influencing the proepicardium formation, where overexpression of Notch intracellular receptor in the endothelium enhances BMP expression and increases the number of phospho-Smad1/5 + cells for enhancing the formation of the proepicardium[ 24 ].…”

Section: Signaling Pathways During Cardiogenesismentioning

confidence: 99%

Cardiac stem cells: Current knowledge and future prospects

Mehanna¹,

Essawy²,

Barkat³

et al. 2022

WJSC

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Regenerative medicine is the field concerned with the repair and restoration of the integrity of damaged human tissues as well as whole organs. Since the inception of the field several decades ago, regenerative medicine therapies, namely stem cells, have received significant attention in preclinical studies and clinical trials. Apart from their known potential for differentiation into the various body cells, stem cells enhance the organ's intrinsic regenerative capacity by altering its environment, whether by exogenous injection or introducing their products that modulate endogenous stem cell function and fate for the sake of regeneration. Recently, research in cardiology has highlighted the evidence for the existence of cardiac stem and progenitor cells (CSCs/CPCs). The global burden of cardiovascular diseases’ morbidity and mortality has demanded an in-depth understanding of the biology of CSCs/CPCs aiming at improving the outcome for an innovative therapeutic strategy. This review will discuss the nature of each of the CSCs/CPCs, their environment, their interplay with other cells, and their metabolism. In addition, important issues are tackled concerning the potency of CSCs/CPCs in relation to their secretome for mediating the ability to influence other cells. Moreover, the review will throw the light on the clinical trials and the preclinical studies using CSCs/CPCs and combined therapy for cardiac regeneration. Finally, the novel role of nanotechnology in cardiac regeneration will be explored.

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“…Specification, differentiation and development of cardiac progenitors are subjected to intense paracrine regulation mediated by different growth factors, particularly bone morphogenetic proteins (Bmps), fibroblastic growth factors (Fgfs), transforming growth factors (Tfgs) and Wnt signaling [ 1 , 2 , 3 ]. Importantly, these growth factor signals also contribute to additional cardiac morphogenetic processes, such as proepicardial/epicardial development [ 4 , 5 , 6 , 7 , 8 , 9 ], endocardial cushion formation [ 10 , 11 , 12 , 13 , 14 , 15 , 16 ] and outflow tract remodeling [ 14 , 17 , 18 , 19 ]. In addition, several other signaling pathways are also required for discrete cardiovascular morphogenetic processes, such as Hippo pathway that is fundamental for cardiomyocyte proliferation and organ size determination [ 20 , 21 , 22 ], and Notch and neuregulin signaling pathways [ 23 , 24 , 25 , 26 , 27 , 28 , 29 ] that are required for ventricular morphogenesis and maturation.…”

Section: Growth Factor Signalling In Cardiac Morphogenesismentioning

confidence: 99%

Post-Transcriptional Regulation of Molecular Determinants during Cardiogenesis

Lozano-Velasco

García-Padilla

Muñoz-Gallardo

et al. 2022

IJMS

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Cardiovascular development is initiated soon after gastrulation as bilateral precardiac mesoderm is progressively symmetrically determined at both sides of the developing embryo. The precardiac mesoderm subsequently fused at the embryonic midline constituting an embryonic linear heart tube. As development progress, the embryonic heart displays the first sign of left-right asymmetric morphology by the invariably rightward looping of the initial heart tube and prospective embryonic ventricular and atrial chambers emerged. As cardiac development progresses, the atrial and ventricular chambers enlarged and distinct left and right compartments emerge as consequence of the formation of the interatrial and interventricular septa, respectively. The last steps of cardiac morphogenesis are represented by the completion of atrial and ventricular septation, resulting in the configuration of a double circuitry with distinct systemic and pulmonary chambers, each of them with distinct inlets and outlets connections. Over the last decade, our understanding of the contribution of multiple growth factor signaling cascades such as Tgf-beta, Bmp and Wnt signaling as well as of transcriptional regulators to cardiac morphogenesis have greatly enlarged. Recently, a novel layer of complexity has emerged with the discovery of non-coding RNAs, particularly microRNAs and lncRNAs. Herein, we provide a state-of-the-art review of the contribution of non-coding RNAs during cardiac development. microRNAs and lncRNAs have been reported to functional modulate all stages of cardiac morphogenesis, spanning from lateral plate mesoderm formation to outflow tract septation, by modulating major growth factor signaling pathways as well as those transcriptional regulators involved in cardiac development.

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Notch and Bmp signaling pathways act coordinately during the formation of the proepicardium

Cited by 8 publications

References 62 publications

Zebrafish as a Model of Cardiac Pathology and Toxicity: Spotlight on Uremic Toxins

Zebrafish as a Model of Cardiac Pathology and Toxicity: Spotlight on Uremic Toxins

Cardiac stem cells: Current knowledge and future prospects

Post-Transcriptional Regulation of Molecular Determinants during Cardiogenesis

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