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Cited by 71 publications
(16 citation statements)
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“…Only when the ion-exchange resin cholestyramine is administered at the same time as warfarin is absorption likely to be incomplete (Robinson et al, 1971). The second is that the patient is actually taking the prescribed dose (i.e.…”
Section: Discussionmentioning
confidence: 99%
“…Only when the ion-exchange resin cholestyramine is administered at the same time as warfarin is absorption likely to be incomplete (Robinson et al, 1971). The second is that the patient is actually taking the prescribed dose (i.e.…”
Section: Discussionmentioning
confidence: 99%
“…Barbiturates did not affect the absorption of racemic warfarin, but did reduce the absorption of dicumarol (11). Antacid therapy had no effect on the absorption of racemic warfarin (12). The simultaneous ingestion of food interfered with the rate but not the extent of absorption of racemic warfarin in man (13), and actually enhanced the absorption of poorly absorbable dicumarol in one study in man (14).…”
Section: Discussionmentioning
confidence: 99%
“…This is concluded from the shortening of the biological half-life and the increase in the total clearance during concomitant treatment with cholestyramine (Table 1). It has been demonstrated by Robinson, Benjamin & McCormack (1971) that cholestyramine binds strongly warfarin in vitro and thereby decreases its gastrointestinal absorption when administered simultaneously with cholestyramine, Whether warfarin itself or a conjugate of warfarin is secreted into the gut remains to be established. The decrease in the anticoagulant effect during treatment with cholestyramine indicates, however, that the substance which is reabsorbed from the gut might be warfarin itself.…”
Section: Effect Of Cholestyramine On the Anticoagulant Activity Of Wamentioning
confidence: 99%