Cytologic diagnosis of Ewing sarcoma/peripheral neuroectodermal tumor with paired prospective molecular genetic analysis

Sanati, Souzan; Lu, Danielle W.; Schmidt, Edith; Perry, Arie; Dehner, Louis P.; Pfeifer, John D.

doi:10.1002/cncr.22692

Cited by 44 publications

(24 citation statements)

References 39 publications

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“…FNA has not classically been used due to smaller tissue sample and lack of tissue architecture. However, several studies have established the usefulness of FNA in providing accurate diagnosis through the new technology of immunocytochemistry, DNA flow cytometry and molecular genetic studies [2–4]. …”

Section: Discussionmentioning

confidence: 99%

EUS-FNA for the Diagnosis of Retroperitoneal Primitive Neuroectodermal Tumor

Sofi

Thekdi

Nawras

2011

Diagnostic and Therapeutic Endoscopy

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Primitive neuroectodermal tumor (PNET) is a rare “small round blue cell tumor” that is diagnosed by open biopsy or percutaneous biopsy of the lesion under radiologic guidance. In this case report, we present a novel approach to the diagnosis of a retroperitoneal PNET by endoscopic ultrasound- (EUS-) guided fine needle aspiration (FNA). A 35-year-old man presented with the history of left-sided flank pain and swelling of 3-weeks duration. Computerized tomography (CT) scan of his abdomen revealed a 12.8 × 13 × 12.5 cm cystic and solid mass arising from the retroperitoneum and displacing the third and fourth portions of the duodenum. He underwent EUS which revealed a well-circumscribed heterogeneous mass abutting the inferior portion of the stomach. EUS-FNA of the mass revealed malignant cells consistent with primitive neuroectodermal tumor (PNET)/Ewing's sarcoma. EUS-guided FNA is an appropriate technique for diagnosing retroperitoneal PNET/Ewing's sarcoma.

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Section: Discussionmentioning

confidence: 99%

EUS-FNA for the Diagnosis of Retroperitoneal Primitive Neuroectodermal Tumor

Sofi

Thekdi

Nawras

2011

Diagnostic and Therapeutic Endoscopy

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“…[57][58][59][60][61][62] A variety of cytology platforms have been validated for mutation testing. 63 Ninety-eight percent of lung cytology samples were suitable for epidermal growth factor receptor and KRAS mutation testing in a recent study.…”

Section: Targeted Therapies Based On Cytologymentioning

confidence: 99%

Five Top Stories in Cytopathology

Fischer,

Benedict,

Amrikachi

2013

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Cytology relies heavily on morphology to make diagnoses, and morphologic criteria have not changed much in recent years. The field is being shaped predominantly by new techniques for imaging and for acquiring and processing samples, advances in molecular diagnosis and therapeutics, and regulatory issues.Objective.-To review the importance of classical morphology in the future of cytopathology, to identify areas in which cytology is expanding or contracting in its scope, and to identify factors that are shaping the field.Data Sources.-Literature review.Conclusions.-Five stories paint a picture in which classical cytomorphology will continue to have essential importance, both for diagnosis and for improving our understanding of cancer biology. New endoscopy and imaging techniques are replacing surgical biopsies with cytology samples. New molecularly targeted therapies offer a chance for cytology to play a major role, but they pose new challenges. New molecular tests have the potential to synergize with, but not replace, morphologic interpretation of thyroid fine-needle aspirations. Ultrasound-guided fine-needle aspiration performed by cytopathologists is opening a new field of ''interventional cytopathology'' with unique value. For the productive evolution of the field, it will be important for cytopathologists to play an active role in clinical trials that document the ability of cytology to achieve cost-effective health care outcomes.(Arch Pathol Lab Med. 2013;137:894-906; doi: 10.5858/ arpa.2012-0258-SA) THE CONTINUING VALUE OF CYTOMORPHOLOGY C ytopathologists have been primarily morphologists, using the smallest possible biopsy specimen for diagnosis. It is unusual for new diagnostic morphologic features to be discovered. A rare example is the description of intranuclear cytoplasmic inclusions in at least a subset of pancreatic intraductal papillary mucinous neoplasms.1 The new Bethesda system for reporting thyroid cytopathology is certainly important, but the actual morphologic criteria for diagnosing thyroid fine-needle aspirations (FNAs) have scarcely changed in the past several decades. It seems that classical cytomorphology has brought the field about as far as it can go.Though new diagnostic cytomorphologies are not likely to help the productive evolution of cytology, the theme of this first story is that classical morphology will continue to have an essential value. In order to provide new useful clinical applications, cytopathology needs to be redefined as the field that uses the smallest possible biopsy specimen for diagnosis by using any technique. The full value of classical cytomorphology can be boosted by new technologies, including improvements in cell block techniques 2-4 and better microbiopsy needles. 5 The use of ultrasound guidance for cytopathologist-performed FNA and the development of new endoscopic techniques have provided new applications for classical cytomorphology. New immunofluorescent microscopy techniques are promising to synergize with classical cytomorphologic diagnosis...

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“…1-3 Since its initial description by James Ewing in 1921, 4 ES remains a neoplasm of unclear pathogenesis. More than 50% of ES cases originate in the pelvis and long bones, 256 with distant dissemination at diagnosis being the rule rather than the exception, reflecting its aggressive biological behavior.…”

Section: Introductionmentioning

confidence: 99%

Ewing\'s Sarcoma of Mandible: An Impressive Case of Spontaneous Mandible Regeneration

Chatzistefanou

Kabesi

Paraskevopoulos

et al. 2016

International Journal of Clinical Pediatric Dentistry

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Ewing’s sarcoma (ES) is an uncommon aggressive bone malignancy that mainly affects children and adolescents. Mandible involvement is quite rare and usually represents metastasis from another skeletal site. Combined therapy including wide surgical resection and preoperative and postoperative chemotherapy has been demonstrated as the mainstay of therapeutic approach. As improved therapeutic modalities have significantly increased survival over the last decades, functional and esthetic reconstruction of the postmandibulectomy defect is usually necessary for patient’s total rehabilitation. We report a case of ES of the mandible with special consideration to the postresection spontaneous structural and functional regeneration of the mandible.How to cite this articleChatzistefanou I, Kabesi S, Paraskevopoulos K, Koliouskas D, Antoniades K. Ewing’s Sarcoma of Mandible: An Impressive Case of Spontaneous Mandible Regeneration. Int J Clin Pediatr Dent 2016;9(3):273-277.

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Cytologic diagnosis of Ewing sarcoma/peripheral neuroectodermal tumor with paired prospective molecular genetic analysis

Cited by 44 publications

References 39 publications

EUS-FNA for the Diagnosis of Retroperitoneal Primitive Neuroectodermal Tumor

EUS-FNA for the Diagnosis of Retroperitoneal Primitive Neuroectodermal Tumor

Five Top Stories in Cytopathology

Ewing\'s Sarcoma of Mandible: An Impressive Case of Spontaneous Mandible Regeneration

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