ChemInform Abstract: Proline‐Catalyzed Direct Asymmetric Aldol Reactions.

List, Benjamin; Lerner, Richard A.; Barbas, Carlos F.

doi:10.1002/chin.200022046

Cited by 1 publication

(2 citation statements)

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“…Some of them, according to their activity and enantioselectivity, do not act as metal-complex catalysts. The aldol reaction is widely regarded to be one of the most important carbon-carbon bond-forming utilized in organic synthesis (List et al, 2010). The catalytic enantioselective carbon-carbon bond-forming is a significant problem in the synthesis of biologically active substances.…”

Section: Cumulative Propertiesmentioning

confidence: 99%

“…The low price and wide spread availability in two enantiometric forms are among the advantages of L-proline as a catalyst. Proline, as a small molecular compound, can be used for direct intramolecular aldol condensation (List et al, 2010), and many reactions with proline can be performed in industrial production. It is also important that the reaction be conducted in the room conditions without inert medium, requiring no transformations of the carbonyl substrate; that is, with neither deprotonation nor stimulation during reaction.…”

Section: Cumulative Propertiesmentioning

confidence: 99%

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Synthesis of a synthetic analogue for the Sitophilus weevil aggregation pheromone and study on its hygienic and toxicological indexes

Shakirzyanova

Romanova²,

Babaev

et al. 2021

AAS

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The work was initiated to study hygienic and toxicological indices of a synthetic analogue for the Sitophilus weevil aggregation pheromone. The toxicity testing of 5-hydroxy-4-methyl-3-heptanone demonstrated its extremely low toxicity for the warm-blood animals, as compared to the one of the typical pesticides. The average lethal dose of the product per orally administered to the white mice was established to be 4375.0 mg kg-1 LD16 and LD84 being 2225.0 mg kg-1 and 6550.0 mg kg-1, respectively. The average lethal dose for rabbits was 5900.0 mg kg-1 5-hydroxy-4-methyl-3-heptanone proved to have a mild skin and conjunctival irritant action, and equally mild functional cumulation. As to chronic toxicity, the acceptable daily dose of 4.3 mg/person/d was calculated and scientifically substantiated. The odor threshold was determined at the dose ranging from 0.35 to 0.7 mg l-1 with the practical limit ranging from 0.35 to 1.5 mg l-1, taste sensation threshold was found at the dose ranging from 1.0 to 3.0 mg l-1 with the practical limit ranging from 3.0 to 7.0 mg l-1

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Section: Cumulative Propertiesmentioning

confidence: 99%

Section: Cumulative Propertiesmentioning

confidence: 99%