2009
DOI: 10.1002/chem.200901444
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Abstract: An easily prepared supported copper hydroxide on titanium oxide (Cu(OH)(x)/TiO(2)) showed high catalytic performance for the 1,3-dipolar cycloaddition of organic azides to terminal alkynes in non-polar solvents under anaerobic conditions. The reactions of various combinations of organic azides (four examples, including aromatic and aliphatic ones) and terminal alkynes (eleven examples, including aromatic, aliphatic, and double bond-containing ones) exclusively proceeded to give the corresponding 1,4-disubstitu… Show more

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Cited by 106 publications
(42 citation statements)
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References 71 publications
(78 reference statements)
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“…In recent years, researchers are dedicating their efforts to find alternative methodologies for waste minimization in fine chemicals and drugs manufacturing processes by replacing the stoichiometric organic synthesis methodologies, which uses large amounts of inorganic and organic reagents with cleaner, catalytic methodologies [17].…”
Section: Introductionmentioning
confidence: 99%
“…In recent years, researchers are dedicating their efforts to find alternative methodologies for waste minimization in fine chemicals and drugs manufacturing processes by replacing the stoichiometric organic synthesis methodologies, which uses large amounts of inorganic and organic reagents with cleaner, catalytic methodologies [17].…”
Section: Introductionmentioning
confidence: 99%
“…[9] The heterogenization of click catalysts constitutes an appealing alternative due to the advantages of easy removal, recovery and reusability that they offer. This heterogenization has been attained by the covalent and non-covalent immobilization of copper species onto a variety of supports such as activated carbon, [10] zeolites, [11] titanium oxide, [12] alumina, [13] aluminium oxyhydroxide fibers, [14] silica, [15] crosslinked poly(ethyleneimine), [16] basic Amberlyst, [17] Tentagel Resin, [18] polystyrene, [15b] ionic polymers, [19] biopolymers [20] and carbon nantotubes. [21] In some of these heterogeneous catalysts, the immobilization of amine-based ligands with a contrasted ability as homogeneous click mediators for the synergetic exploitation of their Cu(I) chelating capabilities and base character has demonstrated to be an efficient approach for the design of such hybrid materials.…”
Section: Introductionmentioning
confidence: 99%
“…The development of easily recoverable and recyclable heterogeneous catalysts can solve the problems of the homogeneous systems and has received a particular research interest. 4,5 In this paper, we report that easily prepared inexpensive supported copper hydroxides, Cu(OH) x /Al 2 O 3 and Cu(OH) x / TiO 2 , 6 can act as efficient heterogeneous catalysts for the Nalkylation of primary amines and ammonia (in situ generated from urea or aqueous ammonia) with alcohols. Generally, copper-catalyzed N-alkylation reactions require high H 2 pressures (²100 atm), high reaction temperatures (²160°C), and/or stoichiometric amounts of bases (e.g., K 2 CO 3 ) to attain high yields of desired amines.…”
mentioning
confidence: 99%