1995
DOI: 10.1002/bies.950170405
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Abstract: Expression and transposition of the Suppressor-mutator (Spm) transposon of maize are controlled by interacting epigenetic and autoregulatory mechanisms. Methylation of critical element sequences prevents both transcription and transposition, heritably inactivating the element. The promoter, comprising the terminal 0.2 kb of the element, and a 0.35-kb, highly GC-rich, downstream sequence are the methylation target sequences. The element encodes two proteins necessary for transposition, TnpA and TnpD. There are … Show more

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Cited by 68 publications
(26 citation statements)
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“…Inhibiting either cytosine methylation or histone deacetylation is sufficient for the derepression of the inactive set of rRNA genes, suggesting that these processes are partners required together for rRNA gene silencing. These results agree well with what is known about the roles of DNA methylation and/or histone acetylation in other epigenetic phenomena such as suppression of silent mating type and telomere-proximal genes in yeast (Aparicio et al 1991;Grunstein 1992), X-inactivation and gametic imprinting in mammals (Rainier and Feinberg 1994;Rastan 1994;Razin and Cedar 1994;Penny et al 1996;Willard 1996), and suppression/activation of transposition and homology-dependent gene silencing in plants (Flavell 1994;Martienssen and Baron 1994;Matzke et al 1994;Federoff et al 1995;Jorgensen 1995). Specific genes analyzed in regard to these other epigenetic phenomena are typically proteincoding genes transcribed by RNA Pol II.…”
Section: A Role For Gene Silencing In Nucleolar Dominancesupporting
confidence: 80%
“…Inhibiting either cytosine methylation or histone deacetylation is sufficient for the derepression of the inactive set of rRNA genes, suggesting that these processes are partners required together for rRNA gene silencing. These results agree well with what is known about the roles of DNA methylation and/or histone acetylation in other epigenetic phenomena such as suppression of silent mating type and telomere-proximal genes in yeast (Aparicio et al 1991;Grunstein 1992), X-inactivation and gametic imprinting in mammals (Rainier and Feinberg 1994;Rastan 1994;Razin and Cedar 1994;Penny et al 1996;Willard 1996), and suppression/activation of transposition and homology-dependent gene silencing in plants (Flavell 1994;Martienssen and Baron 1994;Matzke et al 1994;Federoff et al 1995;Jorgensen 1995). Specific genes analyzed in regard to these other epigenetic phenomena are typically proteincoding genes transcribed by RNA Pol II.…”
Section: A Role For Gene Silencing In Nucleolar Dominancesupporting
confidence: 80%
“…This could be interpreted as a response of the plant to increases in the level of Ac transposase or as an autoregulatory mechanism. Similarly, Spm:tnpA can protect Spm from methylation but may also act as a repressor of Spm (73,74). Additionally, some deleted Spm elements can repress full length Spm elements in trans (75) .…”
Section: Coadaptations To Mitigate Reduced Host Fitnessmentioning
confidence: 99%
“…An alternative explanation is that the up-regulation of RSI in stamen and carpels directs the activation or repression of genes that are normally imprinted in the maternal or paternal genomes, respectively. This latter view would favour the idea of RSI as a TNPAlike protein able to exert a de-methylation/activation function as previously proposed for the En/Spm tnpA gene (FedoroV et al 1995). More extensive studies are required to unravel the functions of this unique CACTA transposon and to clarify the involvement of RSI in Xoral development as well as in seed development.…”
Section: Seed Phenotypesmentioning
confidence: 83%
“…Ultimately, the TNPA can act as a positive and negative regulator of its own activity (McClintock 1965). This function is complex and involves both an auto-regulatory mechanism and DNA methylation "states" of a GC-rich region within the element (FedoroV et al 1995). Very little is known how the methylation "states" (epigenetic states) of these cis-regulatory regions are established.…”
Section: Introductionmentioning
confidence: 99%