2016
DOI: 10.1002/app.43523
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Abstract: A series of nanocomposite scaffolds of poly(E-caprolactone) (PCL) and starch with a range of porosity from 50 to 90% were fabricated with a solvent-casting/salt-leaching technique, and their physical and mechanical properties were investigated. X-ray diffraction patterns and Fourier transform infrared spectra confirmed the presence of the characteristic peaks of PCL in the fabricated scaffolds. Microstructure studies of the scaffolds revealed a uniform pore morphology and structure in all of the samples. The e… Show more

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Cited by 49 publications
(31 citation statements)
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“…Many biocompatible and biodegradable synthetic scaffolds have been developed for bone tissue engineering applications, such as polylactic acid (PLA), poly lactide-co-glycolide (PLGA), polycaprolactone (PCL) and polyurethane (PU). [10][11][12][13] Inclusion of PLA is an excellent way of modifying the mechanical properties and the degradation rate when developing biomaterials for specific applications. The porosity of the scaffold facilitates cell migration, ingrowth, and effective nutrient distribution and waste removal.…”
Section: Introductionmentioning
confidence: 99%
“…Many biocompatible and biodegradable synthetic scaffolds have been developed for bone tissue engineering applications, such as polylactic acid (PLA), poly lactide-co-glycolide (PLGA), polycaprolactone (PCL) and polyurethane (PU). [10][11][12][13] Inclusion of PLA is an excellent way of modifying the mechanical properties and the degradation rate when developing biomaterials for specific applications. The porosity of the scaffold facilitates cell migration, ingrowth, and effective nutrient distribution and waste removal.…”
Section: Introductionmentioning
confidence: 99%
“…To address these requirements, conventional fabrication methods and solid freeform fabrication (SFF) methods have been developed. There are various conventional methods for preparing scaffolds, including salt‐leaching, gas‐forming, solvent‐casting (SC), phase separation, and freeze‐drying techniques . Similarly, SFF methods encompass a wide range of procedures, including the use of a stereo lithography apparatus, selective laser sintering, and three dimensional (3D) plotting .…”
Section: Introductionmentioning
confidence: 99%
“…However, these conventional methods have a few drawbacks. For instance, well‐defined pore structures are difficult to obtain due to shrinkage issues . Furthermore, several different salt‐leaching methods require the use of organic solvents for synthetic polymer immersion or high temperature and pressure conditions to enable NaCl particles to penetrate into synthetic polymers .…”
Section: Introductionmentioning
confidence: 99%
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“…Progress requires a complex integration of a number of factors, including, but not limited to: a scaffold with appropriate morphology, physical and mechanical properties, together with degradation rate, to permit integration of the neo-tissue in vivo; chemical and/or biological factors to promote osteogenesis; and a hierarchy of pore sizes that promotes both vascularization and neo-bone formation 1 . Many scaffold materials and fabrication technologies have been explored, including supercritical foaming of carbon dioxide, 3D printing of materials, particle templating, thermally induced phase separation (TIPS) and electrospinning [2][3][4][5] . No single scaffold type has emerged as a generic substrate for the successful engineering of vascularized bone tissue.…”
Section: Introductionmentioning
confidence: 99%