Disordered Pharmaceutical Materials 2016
DOI: 10.1002/9783527652693.ch4
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Cited by 7 publications
(4 citation statements)
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“…The dark interference fringes seen in Figure 4d panel A are bend contours, which indicate curvature of the crystal arising due to strain at the interface of the crystal. 22,23 We hypothesize that this crystal, while defective, is still a single crystal. The reconstructed images Figure 4d, panels C and D are two lattice planes of the crystal and are found in almost the entire area of the crystal shape, while the planes found in Figure 4d, panels A and B (if superimposed) form a third, infocus lattice plane.…”
Section: ■ Results and Discussionmentioning
confidence: 95%
“…The dark interference fringes seen in Figure 4d panel A are bend contours, which indicate curvature of the crystal arising due to strain at the interface of the crystal. 22,23 We hypothesize that this crystal, while defective, is still a single crystal. The reconstructed images Figure 4d, panels C and D are two lattice planes of the crystal and are found in almost the entire area of the crystal shape, while the planes found in Figure 4d, panels A and B (if superimposed) form a third, infocus lattice plane.…”
Section: ■ Results and Discussionmentioning
confidence: 95%
“…Various bulk analytical methods are currently used to characterize the disorder. The majority of these methods characterize a solid at the surface or particulate level such as isothermal micro-calorimetry, dynamic vapor sorption, , atomic force microscopy, , and transmission electron microscopy . The characterization of disorder at the molecular level in the bulk is currently limited to powder XRD , and some spectroscopic methods such as solid-state NMR, Raman, and dielectric spectroscopy .…”
Section: Introductionmentioning
confidence: 99%
“…The majority of these methods characterize a solid at the surface or particulate level such as isothermal micro-calorimetry, 11 dynamic vapor sorption, 12,13 atomic force microscopy, 14,15 and transmission electron microscopy. 16 The characterization of disorder at the molecular level in the bulk is currently limited to powder XRD 17,18 and some spectroscopic methods such as solid-state NMR, 19−29 Raman, 30 and dielectric spectroscopy. 31 Single crystal XRD is a fundamental method in crystallography that provides detailed information about the internal lattice of a crystalline material and the nature of the disorder; 32−34 however, it is not a bulk analysis method.…”
Section: ■ Introductionmentioning
confidence: 99%
“…As a result of this process, defects can be introduced into crystalline APIs. These defects are known to be sites that can initiate polymorphic phase transformations and hydrate formation (Byard et al ., 2005 ; Koivisto et al ., 2006 ; Eddleston et al ., 2010 ; Eddleston & Jones, 2016 ). Additionally, crystalline defects at particular crystal faces can influence dissolution rates, due to a change in interfacial dissolution kinetics, governed by the energetics of the free surface (Macpherson & Unwin, 1995 ).…”
Section: Introductionmentioning
confidence: 99%