Handbook of Contemporary Neuropharmacology 2007
DOI: 10.1002/9780470101001.hcn045
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Abstract: This chapter will address recent developments in the treatment of migraine. The recent promising clinical trials using a new antimigraine medication, BIBN4096BS, heralds the advent of a new generation of therapeutics. BIBN4096BS targets the receptor for the neuropeptide calcitonin gene–related peptide (CGRP), which appears to play a causal role in migraine pain. We will discuss the rationale and therapeutic implications of modulating CGRP, including its potential for acting at multiple sites in the trigeminova… Show more

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Cited by 2 publications
(1 citation statement)
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“…1 ), which demonstrated efficacy and safety in phase II trials as an anti-migraine agent. 1,2 In addition, DHQs with potent anti-HIV, 3 anti-psychotic, 4,5 anti-cancer 6,7 and anti-microbial 8 activities as well as potential for the treatment of cardiovascular 9 and anti-inflammatory disorders 10 have been disclosed. Recently PFI-1, a potent and selective inhibitor of the bromo- and extra C-terminal domain (BET) family of bromodomains was developed using a fragment based approach starting from small DHQ-containing hit.…”
Section: Introductionmentioning
confidence: 99%
“…1 ), which demonstrated efficacy and safety in phase II trials as an anti-migraine agent. 1,2 In addition, DHQs with potent anti-HIV, 3 anti-psychotic, 4,5 anti-cancer 6,7 and anti-microbial 8 activities as well as potential for the treatment of cardiovascular 9 and anti-inflammatory disorders 10 have been disclosed. Recently PFI-1, a potent and selective inhibitor of the bromo- and extra C-terminal domain (BET) family of bromodomains was developed using a fragment based approach starting from small DHQ-containing hit.…”
Section: Introductionmentioning
confidence: 99%