Streptozotocin‐Induced Diabetic Models in Mice and Rats

Furman, Brian L.

doi:10.1002/0471141755.ph0547s70

Cited by 803 publications

(548 citation statements)

References 50 publications

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“…Diabetes merupakan kondisi hiperglikemia dengan KGD yang diukur setelah puasa yaitu bernilai 150 mg/dL (Furman, 2015) dengan adanya gejala polyfagia, polydypsia, dan polyurea (Kolluru et al, 2012;Patel et al, 2012). Induksi STZ menyebabkan terjadinya DM tipe 1 yang ditandai dengan penyusutan berat badan (Wang et al, 2014).…”

Section: Hasil Pengamatan Parameter Diabetesunclassified

Effect of Diabetes Condition on Topical Treatment of Binahong Leaf Fraction in Wound Healing Process

et al. 2017

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Diabetes mellitus (DM) is a metabolic disease which is becoming the first number of health problem in test begins with ethanolic extract of binahong leaf fractionation to produce fractions of hexane (FHDB), chloroform (FKDB), ethyl acetate (FEADB), and ethanol (FEDB). Water fraction (FADB) was obtained from ethanolic leaf extract residues of binahong leaf extraction. Each fraction activity was tested topically twice daily on dorsal of test animals that created wounds using a punch biopsy 5 mm diameters. Grouping of test animals were divided into 13 groups with normal control group (non diabetes), negative control (diabetes + topical application of biocream®), positive control

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Section: Hasil Pengamatan Parameter Diabetesunclassified

Effect of Diabetes Condition on Topical Treatment of Binahong Leaf Fraction in Wound Healing Process

et al. 2017

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“…Diabetes was induced in overnight-fasted rats by single intraperitoneal injection of freshly prepared STZ (45 mg/kg body weight) in 0.1 M citrate buffer, pH 4.5 [57]. Hyperglycemia was corroborated by checking the blood glucose (by ACCU-CHEK sensor glucometer) after 48 h of STZ injection.…”

Section: In Vivo Studymentioning

confidence: 99%

Effect of Silver Nanoparticle-Mediated Wound Therapy on Biochemical, Hematological, and Histological Parameters

Chauhan

Shrivastava

Prasad

et al. 2018

Asian J Pharm Clin Res

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Methods: Extraction of Syzygium cumini was done and was used for silver nanoparticle synthesis. The synthesized nanoparticles were characterized by ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscopy, and transmission electron microscopy, which confirms the availability of nanosilver particles with marginally spherical morphology. The particles were then carried forward for treating impaired diabetic wounds in Wistar rat models. Regular photography was done and wound healing parameters were monitored throughout the study along with analyzing other parameters such as biochemical, hematological, and histological parameters. Results:The study showed that the sizes of the synthesized nanoparticles are below 100 nm. The results obtained from in vivo studies showed efficient wound healing potential of silver nanoparticles as compared to pre-existing drug povidone-iodine, i.e., the percentage reduction in wound area after therapy is 96.09% in case of biosynthesized silver nanoparticle-treated group, 97.7% reduction in chemically synthesized silver nanoparticle-treated group, 64.28% reduction in case of pre-existing drug povidone-iodine-treated group, 37.5% reduction in case of diabetic control group (diabetic), and 97.5% reduction in normal control group (non-diabetic). Results showed that biosynthesized silver nanoparticles showed less toxicity with respect to liver and kidney functions. Skin histology results showed increased sign of wound healing in biosynthesized silver nanoparticles. Hematology results showed no such variation. Conclusion:The study will help to synthesize new economically viable potential biosynthesized nanoparticles along with providing the approach to develop the medication at nanoscale level.

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“…Treating a healthy young rat or mouse with a pancreatic beta cell toxin such as streptozotocin (STZ) destroys some pancreatic beta cells, reduces beta cell mass and function and generates an animal with hyperglycaemia [22][23][24]. To study the effect of a proposed "anti-diabetic" compound in such a model is really a toxicology study testing the effect of the intervention on the toxicity of STZ.…”

Section: An Animal Model For the Study Of The Effects Open Access Httmentioning

confidence: 99%

“…It is also possible to supplement the treatments with STZ to induce hyperglycaemia but this generates mice of poor health and the utility of this, model may not be ideal in terms of mimicking the effect of diabetes on atherosclerosis in humans. The model may be improved by administering low-dose insulin to the mice [23].…”

Section: An Animal Model For the Study Of The Effects Of Drugs On Thementioning

confidence: 99%

Animal Models for the Evaluation of the Cardiometabolic Therapeutic Potential of Traditional Chinese and Natural Product Medicines

Cao¹,

Kamato²,

Pj³

2017

IJDVR

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Streptozotocin‐Induced Diabetic Models in Mice and Rats

Cited by 803 publications

References 50 publications

Effect of Diabetes Condition on Topical Treatment of Binahong Leaf Fraction in Wound Healing Process

Effect of Diabetes Condition on Topical Treatment of Binahong Leaf Fraction in Wound Healing Process

Effect of Silver Nanoparticle-Mediated Wound Therapy on Biochemical, Hematological, and Histological Parameters

Animal Models for the Evaluation of the Cardiometabolic Therapeutic Potential of Traditional Chinese and Natural Product Medicines

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