Bacteriological Study of Cyanoacrylate Tissue Adhesives

Matsumoto, Teruo; Dobek, Arthur S.; Pani, K. C.; Kovaric, John J.; Hamit, Harold F.

doi:10.1001/archsurg.1968.01340030187023

Cited by 10 publications

(4 citation statements)

References 3 publications

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“…The BCTA returns the tear fluid content of the enzyme to normal levels, indicating a decrease in leakage of proteins from conjunctival vessels 12,14,15 . BCTA also has anti‐infectious properties, being bacteriostatic to gram positive organisms 15,18,19,20–23 …”

Section: Discussionmentioning

confidence: 99%

“…12,14,15 BCTA also has anti-infectious properties, being bacteriostatic to gram positive organisms. 15,18,19,[20][21][22][23] The ocular toxicity of cyanoacrylate tissue adhesive varies according to the chemical composition and quantity of the adhesive used, and is related to the breakdown products (primarily formaldehyde) released during polymerization and degradation. Developmental advances in the chemical formulation has minimized tissue toxicity.…”

Section: Discussionmentioning

confidence: 99%

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Cyanoacrylate tissue adhesive for treatment of refractory corneal ulceration

Bromberg¹

2002

Veterinary Ophthalmology

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Isobutyl cyanoacrylate tissue adhesive (BCTA) was used in the treatment of refractory superficial corneal ulcers in 17 dogs, one cat, and one rabbit, present 2 weeks to 7 months (mean 6.8 weeks +/- 6.1) prior to referral. Little to no sedation was required in the majority of cases, with only topical anesthetic applied prior to debridement and BCTA application. The presence of the tissue adhesive caused mild discomfort for several days after application, as reported by the owners. The ulcers healed, and the tissue adhesive sloughed in approximately 3 weeks (+/- 1 week). Mild neovascularization of the cornea resolved with topical corticosteroids. The use of BCTA offers a simple, safe and noninvasive treatment for refractory corneal ulcers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cyanoacrylate tissue adhesive for treatment of refractory corneal ulceration

Bromberg¹

2002

Veterinary Ophthalmology

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“…These compounds are minimally histotoxic, inciting only a mild, giant cell response (16,(18)(19)(20)(21)(22). They are easy to handle, can be chemically modified to alter polymerization time and viscosity, are shelf stable, and are simple to sterilize using routine ethylene oxide methods (23)(24)(25)(26). These compounds are nonantigenic and implantation in various laboratory animals for as long as 19 months has not been associated with neoplasia (22,23).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of N-Butyl 2-Cyanoacrylate for the Fixation of Osteochondral Fractures

Gorse¹,

Aron²,

Rowland³

et al. 1991

Vet Comp Orthop Traumatol

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SummaryUnstable osteochondral fractures were created on one medial femoral condyle of 39 adult rabbits. The fractures were repaired with n-butyl cyanoacrylate adhesive in 21 rabbits. The remaining fractures were not repaired. Radiographs were made at frequent intervals. The rabbits were euthanatized at 4, 6, 8, 12, and 16 weeks after surgery. The alignment and stability of the osteochondral fragments were assessed, followed by collection of sections of the medial femoral condyles for histological evaluation. Radiologically, the adhesive repaired fractures healed by primary bone union. The adhesive repaired fractures were significantly (p <0.05) better aligned and more stable than the non-repaired fractures at necropsy. Histologically, there was healing of the subchondral fracture lines of adhesive repaired fractures. The articular cartilage overlying the healing fragments was normal or had only minor surface irregularities.

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“…This is, to our knowledge, the only publication describing actual bacterial growth on a cyanoacrylate, and our own results with a different strain of this biofilm former organism are contrary to those reported in that article. Matsumoto et al 14 have described the absence of bacteriostatic and bactericidal effects in vitro for individual monomers of n-butyl, isobutyl, and methyl-2 cyanoacrylate. Finally, Jang et al 15 have shown no in vitro antibacterial activity of octylcyanoacrylate against clinical strains of P. aeruginosa isolated from otitis media patients, which is consistent with other results discussed above regarding gram-negative bacteria.…”

Section: Discussionmentioning

confidence: 99%

Effect on Microbial Growth of a New Skin Protectant Formulation

Stoffel¹,

Bernatchez

2017

Advances in Wound Care

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Objective: Evaluate the effect of a new investigational skin protectant formulation on the growth of various microorganisms in vitro.Approach: An in vitro laboratory assay with various species of gram-positive bacteria, gram-negative bacteria, and yeast grown on agar plates was used to verify that a new investigational product used for the management of incontinence-associated dermatitis (IAD) does not support microbial growth.Results: The investigational product did not support the growth of all organisms tested for 48 h in these assays. The results demonstrate the barrier properties of this investigational formulation against bacteria and yeast that are relevant to incontinent patients.Innovation: IAD accompanied by skin damage is difficult to manage with currently available products. A new skin protectant that can be applied as a liquid and polymerizes into a breathable film in situ even in the presence of exudate (as shown previously) has been developed and tested to ensure that it does not support microbial growth.Conclusion: This work verifies that this new product does not support microbial growth in vitro using organisms relevant for the intended application.

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Bacteriological Study of Cyanoacrylate Tissue Adhesives

Cited by 10 publications

References 3 publications

Cyanoacrylate tissue adhesive for treatment of refractory corneal ulceration

Cyanoacrylate tissue adhesive for treatment of refractory corneal ulceration

Evaluation of N-Butyl 2-Cyanoacrylate for the Fixation of Osteochondral Fractures

Effect on Microbial Growth of a New Skin Protectant Formulation

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