Treatment of Posttraumatic Stress Disorder With Amitriptyline and Placebo

Davidson, Jonathan

doi:10.1001/archpsyc.1990.01810150059010

Cited by 313 publications

(124 citation statements)

References 20 publications

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“…Á Double-blind studies found amitriptyline to be superior to placebo (Davidson et al 1990(Davidson et al , 1993a)(B). Á In a comparison with phenelzine, imipramine was superior to placebo.…”

Section: )(A)tricyclic Antidepressants (Tcas)mentioning

confidence: 99%

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders – First Revision

Bandelow

Zohar

Hollander

et al. 2008

The World Journal of Biological Psychiatry

696

400

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In this report, which is an update of a guideline published in 2002 (Bandelow et al. 2002, recommendations for the pharmacological treatment of anxiety disorder, obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD) are presented. Since the publication of the first version of this guideline, a substantial number of new randomized controlled studies of anxiolytics have been published. In particular, more relapse prevention studies are now available that show sustained efficacy of anxiolytic drugs. The recommendations, developed by the World Federation of Societies of Biological Psychiatry (WFSBP) Task Force for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders, a consensus panel of 30 international experts, are now based on 510 published randomized, placebo-or comparator-controlled clinical studies (RCTs) and 130 open studies and case reports. First-line treatments for these disorders are selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs) and the calcium channel modulator pregabalin. Tricyclic antidepressants (TCAs) are equally effective for some disorders, but many are less well tolerated than the SSRIs/ SNRIs. In treatment-resistant cases, benzodiazepines may be used when the patient does not have a history of substance abuse disorders. Potential treatment options for patients unresponsive to standard treatments are described in this overview. Although these guidelines focus on medications, non-pharmacological were also considered. Cognitive behavioural therapy (CBT) and other variants of behaviour therapy have been sufficiently investigated in controlled studies in patients with anxiety disorders, OCD, and PTSD to support them being recommended either alone or in combination with the above medicines.

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Section: )(A)tricyclic Antidepressants (Tcas)mentioning

confidence: 99%

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders – First Revision

Bandelow

Zohar

Hollander

et al. 2008

The World Journal of Biological Psychiatry

696

400

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“…However, it is being increasingly recognized as a valuable part of a multidimensional treatment approach to chronic PTSD in adults (Sutherland & Davidson, 1994). In several controlled trials with adult PTSD patients (Davidson et al, 1993 ;Frank, Kosten, Giller, & Dan, 1988 ;Schestatzky, Greenberg, & Lerer, 1988), drugs with serotonergic action (TCAs, MAOIs, and SSRIs) have achieved the most positive effects, with the best results achieved after longer treatment trials (8 weeks or longer) (Sutherland & Davidson, 1994). While PTSD symptoms may be so intolerable or debilitating that pharmacotherapy may be needed, there is no evidence from the adult PTSD literature that pharmacotherapy alone is sufficient to cure PTSD (Shalev et al, 1996).…”

Section: Pharmacological Treatmentsmentioning

confidence: 99%

Practitioner Review: The Assessment and Treatment of Post‐traumatic Stress Disorder in Children and Adolescents

Perrin

Smith

Yule

2000

Child Psychology Psychiatry

183

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Post-traumatic Stress Disorder (PTSD) is a syndrome defined by the intrusive reexperiencing of a trauma, avoidance of traumatic reminders, and persistent physiological arousal. PTSD is associated with high levels of comorbidity and may increase the risk for additional disorders over time. While controversies remain regarding the applicability of the PTSD criteria to very young children, it has proved to be a useful framework for guiding assessment and treatment research with older children and adolescents. This article presents an overview of the literature on the clinical characteristics, assessment, and treatment of PTSD in children and adolescents.

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“…Imipramine, amitriptyline, and desipramine have mixed norepinephrine and 5-HT enhancement as their mechanism of action. All have been tested for efficacy in PTSD in older, small, randomized trials (Frank et al [92], Davidson et al [93], Reist et al [94]). There was modest re-experiencing and hyperarousal symptom improvement from imipramine (d = 0.25), moderate improvement for amitriptyline (d = 0.64), and no benefit from desipramine (d = 0.05).…”

Section: Antidepressant Agentsmentioning

confidence: 99%

Treatment of sleep disturbances in posttraumatic stress disorder: A review

Schoenfeld

DeViva²,

Manber³

2012

JRRD

215

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Abstract-Sleep disturbances are among the most commonly reported posttraumatic stress disorder (PTSD) symptoms. It is essential to conduct a careful assessment of the presenting sleep disturbance to select the optimal available treatment. Cognitivebehavioral therapies (CBTs) are at least as effective as pharmacologic treatment in the short-term and more enduring in their beneficial effects. Cognitive-behavioral treatment for insomnia and imagery rehearsal therapy have been developed to specifically treat insomnia and nightmares and offer promise for more effective relief of these very distressing symptoms. Pharmacotherapy continues to be an important treatment choice for PTSD sleep disturbances as an adjunct to CBT, when CBT is ineffective or not available, or when the patient declines CBT. Great need exists for more investigation into the effectiveness of specific pharmacologic agents for PTSD sleep disturbances and the dissemination of the findings to prescribers. The studies of prazosin and the findings of its effectiveness for PTSD sleep disturbance are examples of studies of pharmacologic agents needed in this area. Despite the progress made in developing more specific treatments for sleep disturbances in PTSD, insomnia and nightmares may not fully resolve.

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Treatment of Posttraumatic Stress Disorder With Amitriptyline and Placebo

Cited by 313 publications

References 20 publications

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders – First Revision

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders – First Revision

Practitioner Review: The Assessment and Treatment of Post‐traumatic Stress Disorder in Children and Adolescents

Treatment of sleep disturbances in posttraumatic stress disorder: A review

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