Rheumatic Infection in Childhood: Fifteen to Twenty Year Follow-Up

Ash, Rachel

doi:10.1001/archpedi.1948.02030030053005

Cited by 19 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is strong evidence that secondary prophylaxis reduces the severity of RHD by preventing disease progression 171,172 . Studies carried out in the midtwentieth century showed that 40-60% of patients with ARF progress to RHD [173][174][175] and that the rate of regression of mitral regurgitation increased from 20% to 70% after penicillin was introduced 173 . More recently, Lawrence and colleagues 10 studied 1,149 children with ARF (27.5% these children presented with carditis) in the Northern Territory, Australia, and reported that 35% of children with ARF developed RHD by 1 year and 61% had evidence of RHD by 10 years 10 .…”

Section: Preventionmentioning

confidence: 99%

Acute Rheumatic Fever and Rheumatic Heart Disease

McDonald¹

2021

View full text Add to dashboard Cite

Acute rheumatic fever (ARF) is the result of an autoimmune response to pharyngitis caused by infection with group A Streptococcus. The long-term damage to cardiac valves caused by ARF, which can result from a single severe episode or from multiple recurrent episodes of the illness, is known as rheumatic heart disease (RHD) and is a notable cause of morbidity and mortality in resource-poor settings around the world. Although our understanding of disease pathogenesis has advanced in recent years, this has not led to dramatic improvements in diagnostic approaches, which are still reliant on clinical features using the Jones Criteria, or treatment practices. Indeed, penicillin has been the mainstay of treatment for decades and there is no other treatment that has been proven to alter the likelihood or the severity of RHD after an episode of ARF. Recent advances-including the use of echocardiographic diagnosis in those with ARF and in screening for early detection of RHD, progress in developing group A streptococcal vaccines and an

show abstract

Section: Preventionmentioning

confidence: 99%

Acute Rheumatic Fever and Rheumatic Heart Disease

McDonald¹

2021

View full text Add to dashboard Cite

show abstract

“…Once ARF is diagnosed intramuscular injection at least every 28 days with benzathine benzylpenicillin G (BPG) is recommended to prevent ARF recurrences and progression to RHD, with most people requiring this secondary prophylaxis for at least 10 years from the time of ARF/RHD diagnosis. Studies carried out in the mid‐twentieth century showed that 40–60% of patients with ARF progress to RHD 9–11 and that the rate of regression of mitral regurgitation increased from 20 to 70% after penicillin was introduced 9 . Suboptimal adherence to secondary prophylaxis is one of the main challenges to effective control of ARF and RHD, with patients who receive less than 80% of the recommended doses four times more likely to suffer recurrent ARF 12 .…”

mentioning

confidence: 99%

Early diagnosis of acute rheumatic fever and rheumatic heart disease as part of a secondary prevention strategy: Narrative review

Bennett

Rentta

Leung

et al. 2021

J Paediatrics Child Health

View full text Add to dashboard Cite

Acute rheumatic fever (ARF) and its sequela rheumatic heart disease (RHD) remain significant causes of morbidity and mortality. In New Zealand, ARF almost exclusively affects Indigenous M aori and Pacific children. This narrative review aims to present secondary interventions to improve early and accurate diagnosis of ARF and RHD, in order to minimise disease progression in New Zealand. Medline, EMBASE and Scopus databases were searched as well as other electronic publications. Included were 56 publications from 1980 onwards. Diagnosing ARF and RHD as early as possible is central to reducing disease progression. Recent identification of specific ARF biomarkers offer the opportunity to aid initial diagnosis and portable echocardiography has the potential to detect undiagnosed RHD in high-risk areas. However, further research into the benefits and risks to children with subclinical RHD is necessary, as well as an economic evaluation.

show abstract

“…Ash 4 reported that "rest in bed in the presence of active rheumatic infection is recommended regardless of the presence or absence or clinically recognizable heart disease." She also stated:…”

mentioning

confidence: 99%

Early Ambulation in the Treatment of Acute Rheumatic Fever

Grossman¹

1968

Am J Dis Child

View full text Add to dashboard Cite

Rheumatic Infection in Childhood: Fifteen to Twenty Year Follow-Up

Cited by 19 publications

References 8 publications

Acute Rheumatic Fever and Rheumatic Heart Disease

Acute Rheumatic Fever and Rheumatic Heart Disease

Early diagnosis of acute rheumatic fever and rheumatic heart disease as part of a secondary prevention strategy: Narrative review

Early Ambulation in the Treatment of Acute Rheumatic Fever

Contact Info

Product

Resources

About