High-Dose Intravenous Methylprednisolone in Myasthenia Gravis

The diagnosis and treatment of acquired Myasthenia Gravis in two adult dogs using oral neostigmine bromide

“…High dose of intravenous methylprednisolone have been reported to produce rapid improvement in acquired MG patients. However, an initial worsening of the clinical signs have been seen in certain patients after methylprednisolone therapy (Arsura et al, 1985;Munakata et al, 2002). We also observed the deterioration of clinical condition of the patient "A" after IV methylprednisolone.…”

The Effect of Combined Therapy with Immunoadsorption and High-Dose Intravenous Methylprednisolone on Myasthenia gravis

“…These results indicate that IA + HMP for a longer interval (mean, 151 days) is more effective than IA alone for a shorter interval (mean, 29 days). Although we did not compare the effects of IA + HMP and HMP alone in the present study, previous studies have reported that the effect of HMP continued for only 4-14 weeks [16], and that even frequent repetition of HMP (every fifth day intravenous administration of 2,000 mg of methylprednisolone) did not result in complete remission of MG symptoms [17]. In contrast, 4 of the present patients receiving IA + HMP demonstrated remission (no symptom with no medication for more than 1 year).…”

Predictable recovery from myasthenia gravis crisis with plasma exchange: Thirty-six cases and review of current management

“…The highest dose of a three dose trial was most efficacious [18]. This, and a very high dose trial, 2 g methylprednisolone [19], each had some patients in whom recovery from the crisis was very slow. There was a 30% failure rate in the first [18] and the need for PEX in two of the three failures in the other [19].…”