2010
DOI: 10.1177/030089161009600530
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Abstract: Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms which take origin from the neuroendocrine cell system and are characterized by embryological, biological and histopathological differences. Traditionally considered as a rare and "niche" pathology, over the last decades they have gained significant attention from the scientific community, even because of their increasing incidence and prevalence probably imputable to the availability of more sensitive diagnostic tools and to the development of… Show more

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Cited by 18 publications
(15 citation statements)
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References 15 publications
(11 reference statements)
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“…The are similar to almost all other studies in demonstrating that the frequency of occurrence of many of the features of the MEN1 syndrome including HPT; adrenal or pituitary disease; smooth muscle or CNS tumors; bronchial/ gastric carcinoids; or dermatological lesions does not correlate with survival and thus they are not prognostic factors for survival 78,129,150,152,217,251,289,433,444 . In contrast, almost all studies similar to our pooled MEN1/PET literature series, report the presence of thymic carcinoids carries a worse prognosis, due to the aggressive nature of these tumors 111,131,131,150,151,331,413,414,465 . While our NIH MEN1/ZES series showed a trend toward significance for thymic carcinoid patients having a worse prognosis (p=0.098), a number of factors likely contributed to it not reaching full significance as a prognostic factor.…”
Section: Discussionmentioning
confidence: 49%
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“…The are similar to almost all other studies in demonstrating that the frequency of occurrence of many of the features of the MEN1 syndrome including HPT; adrenal or pituitary disease; smooth muscle or CNS tumors; bronchial/ gastric carcinoids; or dermatological lesions does not correlate with survival and thus they are not prognostic factors for survival 78,129,150,152,217,251,289,433,444 . In contrast, almost all studies similar to our pooled MEN1/PET literature series, report the presence of thymic carcinoids carries a worse prognosis, due to the aggressive nature of these tumors 111,131,131,150,151,331,413,414,465 . While our NIH MEN1/ZES series showed a trend toward significance for thymic carcinoid patients having a worse prognosis (p=0.098), a number of factors likely contributed to it not reaching full significance as a prognostic factor.…”
Section: Discussionmentioning
confidence: 49%
“…These include that we made an early diagnosis of thymic carcinoid because all patients were prospectively followed with regular imaging 131 and their treatment was aggressive, because of the known progressive nature 131 of these tumors, resulting in prolonged survivals. A number of large studies of MEN1 patients report that the presence of any PET (except insulinomas), is associated with decreased survival 150,331,389,465 . In our study this could not be evaluated because both groups of our MEN1 patients studied (the 106 NIH patients and the 227 patients from the pooled literature series) all the patients had PETs.…”
Section: Discussionmentioning
confidence: 99%
“…[1] Primary hepatic NET is relatively rare, [2] there were only about 100 cases reported since 1958. [3][4][5] Most of the hepatic NETs are metastasized from pancreas and gastrointestinal tract.…”
Section: Introductionmentioning
confidence: 99%
“…Notwithstanding that NET was initially described by Siegfried Oberndorfer more than a century ago, there are some ambiguities regarding the best way to manage some of its subgroups (including ampullary subtype) 6. This issue may be attributed to its extreme rarity.…”
Section: Discussionmentioning
confidence: 99%