1 Evolution and Development of Distinct Cell Lineages Derived from Somites

Brand‐Saberi, Beate; Christ, Bodo

doi:10.1016/s0070-2153(08)60753-x

Cited by 142 publications

(107 citation statements)

References 44 publications

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“…Finally, as a biological question, the source of fibroblasts is uncertain, and evidence supports their origin from primitive mesenchyme during embryogenesis (Brand-Saberi and Christ 2000), ongoing local generation (Hay 1995) within organ epithelia (the ''epithelialmesenchymal transition'' model), and, perhaps most surprisingly, from hematopoietic stem cells derived from bone marrow (Friedenstein et al 1970;Ogawa et al 2006). Although we hesitate to draw conclusions from a phylogenetic fate map exhibiting low overall accuracy, our experimental map of fibroblasts exhibits features suggestive of cell migration.…”

Section: Discussionmentioning

confidence: 99%

Phylogenetic Fate Mapping: Theoretical and Experimental Studies Applied to the Development of Mouse Fibroblasts

Salipante¹,

Thompson²,

Horwitz

2008

Genetics

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Mutations are an inevitable consequence of cell division. Similarly to how DNA sequence differences allow inferring evolutionary relationships between organisms, we and others have recently demonstrated how somatic mutations may be exploited for phylogenetically reconstructing lineages of individual cells during development in multicellular organisms. However, a problem with such ''phylogenetic fate maps'' is that they cannot be verified experimentally; distinguishing actual lineages within clonal populations requires direct observation of cell growth, as was used to construct the fate map of Caenorhabditis elegans, but is not possible in higher organisms. Here we employ computer simulation of mitotic cell division to determine how factors such as the quantity of cells, mutation rate, and the number of examined marker sequences contribute to fidelity of phylogenetic fate maps and to explore statistical methods for assessing accuracy. To experimentally evaluate these factors, as well as for the purpose of investigating the developmental origins of connective tissue, we have produced a lineage map of fibroblasts harvested from various organs of an adult mouse. Statistical analysis demonstrates that the inferred relationships between cells in the phylogenetic fate map reflect biological information regarding the origin of fibroblasts and is suggestive of cell migration during mesenchymal development.

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Section: Discussionmentioning

confidence: 99%

Phylogenetic Fate Mapping: Theoretical and Experimental Studies Applied to the Development of Mouse Fibroblasts

Salipante¹,

Thompson²,

Horwitz

2008

Genetics

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“…It has been suggested that this occurs progressively in a PD sequence [11]. Alternatively, information regarding the number and anatomic identity of skeletal elements might have been already specified in the corresponding cell lineages by the time of their appearance [12]. In any case, the family of transcription factors encoded by homeobox genes seems to play a key role at this early stage of development.…”

Section: Skeletal Morphogenesismentioning

confidence: 99%

Bone Formation: Biological Aspects and Modelling Problems

Herrero

López

2004

Computational and Mathematical Methods in Medicine

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In this work we succintly review the main features of bone formation in vertebrates. Out of the many aspects of this exceedingly complex process, some particular stages are selected for which mathematical modelling appears as both feasible and desirable. In this way, a number of open questions are formulated whose study seems to require interaction among mathematical analysis and biological experimentation.

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“…They contain multipotent progenitor cells for skeleton, connective tissue, smooth and striated muscles as well as endothelial cells (Brand-Saberi and Christ, 2000;Christ et al, 2007;Ben-Yair and Kalcheim, 2008). One important step for cell differentiation is the somite compartmentalization, which is controlled by signals from the notochord, the dorsal neural tube, the lateral plate mesoderm and the ectoderm, resulting in the subdivision of the somite into a ventral and dorsal part (Brand-Saberi and Christ, 2000;Christ et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…The residual dorsal part maintains the epithelial structure, forming the dermomyotome (DM), which contributes to skeletal muscles and the dorsal dermis Brand-Saberi 2006, 2012). Further somitic derivatives are fibroblasts, smooth muscles, and endothelial cells (Brand-Saberi and Christ, 2000). The myotome is built by the dermomyotomal cells from all four borders which slide ventrally to form a complex of cell sheets (Gros et al, 2004).…”

Section: Introductionmentioning

confidence: 99%