1-Amino-4-phenyl Pyridinium Chloride: a Potential Antihypertensive Agent

Quaternary Pyridinium Compounds

“…It has also been observed that 1-amino4-phenylpyridinium chloride causes a decrease in systolic blood pressure without any change in heart rate, and produces a long lasting antihypertensive effect in renal hypertensive dogs (585,586). However, the reduction of the pyridinium system to a pipendine ring yielded some highly active hypotensive agents (584).…”