1.7 micron optical coherence tomography for vaginal tissue characterization in vivo

Li, Yan; Sudol, Neha T.; Miao, Yusi; Jing, Joseph C.; Zhu, Jiang; Lane, Felicia; Chen, Zhongping

doi:10.1002/lsm.23003

Cited by 20 publications

(20 citation statements)

References 24 publications

(23 reference statements)

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“…In addition, diagnostic accuracy is limited by sample number and size [92][93][94]. To address the limitations of a conventional colonoscopy, endoscopic US, OCT, NIRF, and multiphoton have been applied in the GI tract to visualize the layered architecture and microvasculature, detect early stage disease, and assess treatment response with exogenous optical contrast agents, which represents a significant step toward noninvasive comprehensive characterization of GI disease [3,38,[95][96][97][98][99][100][101][102][103][104][105][106][107][108][109][110][111]. However, one of the key parameters, SO 2 saturation, is still lacking.…”

Section: Gi Tract Applicationmentioning

confidence: 99%

Advances in Endoscopic Photoacoustic Imaging

Zhou

et al. 2021

Photonics

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Photoacoustic (PA) imaging is able to provide extremely high molecular contrast while maintaining the superior imaging depth of ultrasound (US) imaging. Conventional microscopic PA imaging has limited access to deeper tissue due to strong light scattering and attenuation. Endoscopic PA technology enables direct delivery of excitation light into the interior of a hollow organ or cavity of the body for functional and molecular PA imaging of target tissue. Various endoscopic PA probes have been developed for different applications, including the intravascular imaging of lipids in atherosclerotic plaque and endoscopic imaging of colon cancer. In this paper, the authors review representative probe configurations and corresponding preclinical applications. In addition, the potential challenges and future directions of endoscopic PA imaging are discussed.

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Section: Gi Tract Applicationmentioning

confidence: 99%

Advances in Endoscopic Photoacoustic Imaging

Zhou

et al. 2021

Photonics

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“…To further optimize the performance of OCT devices, several studies have reported that OCT devices with a light source centered at 1.7 µm demonstrsted improved penetration depth by up to ~25% through ex-vivo or in-vivo tests [31][32][33]. The imaging depth of OCTA, which is based on OCT, is therefore also enhanced, allowing for mapping vasculature in deeper layers of biological tissue.…”

Section: Introductionmentioning

confidence: 99%

1.7-Micron Optical Coherence Tomography Angiography for Characterization of Skin Lesions–A Feasibility Study

Murthy

Zhu

et al. 2021

IEEE Trans. Med. Imaging

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Optical coherence tomography (OCT) is a noninvasive diagnostic method that offers real-time visualization of the layered architecture of the skin in vivo. The 1.7-micron OCT system has been applied in cardiology, gynecology and dermatology, demonstrating an improved penetration depth in contrast to conventional 1.3-micron OCT. To further extend the capability, we developed a 1.7micron OCT/OCT angiography (OCTA) system that allows for a visualization of both morphology and microvasculature in the deeper layers of the skin. Using this imaging system, we imaged human skin with different benign lesions and described the corresponding features of both structure and vasculature. The significantly improved imaging depth and additional functional information suggest that the 1.7-micron OCTA system has great potential to advance both dermatological clinical and research settings for characterization of benign and cancerous skin lesions.

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“…[7][8][9] There are few groups that attempted to use OCT in female reproductive organs but their focus is mainly on cervix, fallopian tube, vagina, and recently on ovary. [10][11][12][13][14][15][16] Kirillin et al demonstrated accuracy of OCT in Editor: Shogo Hayashi.…”

Section: Introductionmentioning

confidence: 99%

Endometrium imaging using real-time rotational optical coherence tomography imaging system

Law¹,

Wu²,

Xu³

et al. 2019

Medicine

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This study aimed to evaluate a novel real-time rotational optical coherence tomography (OCT) imaging system (OCTIS) with a fiberoptic probe to look at endometrium and to correlate the OCTIS images with standard histology. OCT could obtain real-time images resembling histological examination. With recent development of customized probes, it allows OCT to be used in the field of gynecology.This is a pilot, prospective, ex-vivo and observational study. Women underwent hysterectomy for various gynecological conditions were recruited and OCTIS images were obtained from endometrium of 15 fresh uterus specimens immediately after hysterectomy. The excised uterus was cut open and OCTIS imaging was obtained. The scanned region of endometrium was excised for histological examination and OCTIS images were precisely compared to corresponding histological images and ultrasound images. Blinded qualitative analysis on OCTIS images was performed by 2 assessors to determine inter-rating reliability on the histopathological diagnosis.Epithelium, glands, cysts, and stroma of endometrium were clearly seen by the OCTIS. Different phases of menstrual cycle of normal endometrium could be differentiated and pathological condition such as hyperplastic and dysplasic endometrium, which corresponded well with histological findings, could be identified. The inter-rater reliability between assessors on overall OCTIS endometrium and neoplastic OCTIS endometrium was moderate (Kendall tb of 0.58) and substantial (Kendall tb of 0.76), respectively.OCTIS can provide real-time, high-resolution and rotational imaging modality to view endometrial structure with high consistency with histological examination and satisfactory agreement between observers. It has a great potential to be developed in the clinical use of endometrial assessment for gynecological applications.

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1.7 micron optical coherence tomography for vaginal tissue characterization in vivo

Abstract: The significantly improved performance of the novel 1.7 μm OCT imaging system demonstrates its potential use as a minimally-invasive monitoring tool of vaginal health in gynecologic practice. Lasers Surg. Med. © 2018 Wiley Periodicals, Inc.

Cited by 20 publications

References 24 publications

Advances in Endoscopic Photoacoustic Imaging

Advances in Endoscopic Photoacoustic Imaging

1.7-Micron Optical Coherence Tomography Angiography for Characterization of Skin Lesions–A Feasibility Study

Endometrium imaging using real-time rotational optical coherence tomography imaging system

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