1,10‐Phenanthroline‐Based Molten Salt as a Bifunctional Sulfonic Acid Catalyst: Application to the Synthesis of N‐Heterocycle Compounds via Anomeric Based Oxidation

Abstract

1,10‐phenanthroline‐based molten salt as a bifunctional sulfonic acid [Phen(SO3H)2]Cl2 was designed and synthesized. The described nano molten salt has two SO3H acid groups and a rigid structure that allows the rotation of the molecule to have a unique catalytic ability. This catalyst was applied for the synthesis of N‐heterocyclic compounds such as quinazolines, quinazolinones, acridines and dihydropyridines via multi‐component condensation reactions. These compounds are highly regarded for their medicinal and biological properties. The effect of different functional groups at the corresponding products for developing the new mechanisem entitled “anomeric based oxidation” (ABO) were studied. The major advantages of the presented methodology are mild conditions, high efficiency, short reaction times and reusability of the catalyst.

Catalytic application of sulfamic acid-functionalized magnetic Fe3O4 nanoparticles (SA-MNPs) for protection of aromatic carbonyl compounds and alcohols: experimental and theoretical studies

“…Employing 1,10-phenanthroline-based molten salt as a bifunctional sulfonic acid, which was synthesized by Babaee and co-workers has shown a yield about 62% (entry 12). 28 The reaction failed in the absence of a catalyst (entry 13). The SA-MNPs catalyst was found to be the most effective solid acid for cyclic acetalization and thioacetalization.…”

Synthesis and Application of [Zr-UiO-66-PDC-SO3H]Cl MOFs at The Preparation of Dicyanomethylene Pyridines via Chemical and Electrochemical Methods

“…In this regard, pyridines and 1,4-dihydropyridines are suitable candidates for biological and pharmacological studies. 19,20 These compounds have been applied as drugs for cancer, malaria, HIV, antimicrobial, anti-tumor, antifungal, anticonvulsant, antihypertension and urinary incontinence treatment. [19][20][21][22][23][24][25][26][27] On the other hand, the chemical reactivity is very complex.…”

Synthesis, crystal structure, and quantum mechanical studies regarding a new metal–organic complex based on Cd (II)

“…Phenanthroline has a wide range of biological activities and it is present in bioactive molecules such as metallopeptidase inhibitor. Phenanthrolines have unique properties, such as speci c catalytic ability, selectivity, and eco-friendly behavior [14]. The therapeutic and pharmaceutical properties of phenanthroline compounds can be used to treat cancer, tumor, HIV, malaria, bacterial, fungal, convulsant, and parasitic [15][16][17][18][19][20].…”