010 Advanced glycation end products induce functional impairment in neonatal rat cardiomyocytes through enhanced production of reactive oxygen species

Hegab, Zeinab; Gibbons, Stephen; Mohamed, Tamer; Schelcher, Celine; Shaheen, Mohamed A.; Oceandy, Delvac; Neyses, Ludwig; Mamas, Mamas A.

doi:10.1136/hrt.2010.195941.10

Cited by 2 publications

(3 citation statements)

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“…AGEs affect normal physiological function by forming additional cross-links in connective tissues, and alteration of cellular function by binding to receptors for AGE (RAGE) which can result in the production of reactive oxygen species [9][10][11]. AGE accumulation in tissues has been implicated in diabetic complications such as retinopathy, corneal alterations, nephropathy, neuropathy, and cardiovascular diseases [12][13][14][15][16][17]. The roles of AGEs in diabetic pathogenesis also led to concerns about the diet input of AGEs as the Maillard reaction is accelerated at higher temperatures and leads to food browning [18,19].…”

Section: Introductionmentioning

confidence: 99%

Multiphoton imaging of the monosachharide induced formation of fluorescent advanced glycation end products in tissues

Lin,

Mondal,

Lee

et al. 2023

Journal of Biophotonics

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We studied the in vitro rate of fluorescent AGEs (fAGEs) formation with multiphoton microscopy in different porcine tissues (aorta, cornea, kidney, dermis, and tendon). These tissues were treated with D‐glucose, D‐galactose, and D‐fructose, three primary monosaccharides found in human diets.We found that the use of D‐fructose resulted in the highest glycation rate, followed by D‐galactose and then D‐glucose. Moreover, compared to non‐collagen tissue constituents such as elastic fibers and cells, the rate of tissue glycation was consistently higher in collagen, suggesting that collagen is a more sensitive target for fAGE formation. However, we also found that collagen in different tissues exhibits different rates of fAGE formation, with slower rates observed in tightly packed tissues such as cornea and tendon.Our study suggests that for fAGE to be developed into a long‐term glycemic biomarker, loosely organized collagen tissues located in the proximity of vasculature may be the best targets.This article is protected by copyright. All rights reserved.

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Section: Introductionmentioning

confidence: 99%

Multiphoton imaging of the monosachharide induced formation of fluorescent advanced glycation end products in tissues

Lin,

Mondal,

Lee

et al. 2023

Journal of Biophotonics

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“…The prolonged hyperglycemic condition is a prime mortality factor that partially results from its effect on structural and functional aspect of vital proteins . It is presumed that hyperglycemia enhances the creation of free radicals and reactive oxygen species leading to oxidative tissue damage, which further leads to various complications such as neuropathy, nephropathy, retinopathy, and cardiovascular disorders …”

Section: Introductionmentioning

confidence: 99%

“…[5] It is presumed that hyperglycemia enhances the creation of free radicals and reactive oxygen species leading to oxidative tissue damage, which further leads to various complications such as neuropathy, [6,7] nephropathy, [8,9] retinopathy, [10,11] and cardiovascular disorders. [12,13] The postprandial hyperglycemic condition in patients with diabetes is because of hydrolysis of dietary carbohydrates, which is governed by two enzymes, ie, α-glucosidase and α-amylase. [14,15] Suspension of glucose absorption after a meal by inhibiting these two enzymes is an influential method for the alleviation and treatment of type 2 diabetes mellitus (T2DM).…”

Section: Introductionmentioning

confidence: 99%

Thiazolidine‐4‐one clubbed pyrazoles hybrids: Potent α‐amylase and α‐glucosidase inhibitors with NLO properties

Kumar

Duhan

Sindhu

et al. 2019

Journal of Heterocyclic Chem

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Molecular hybrids based on thiazolidin‐4‐one and pyrazolyl pharmacophore (THZP) as new antidiabetic agents were synthesized. Two sets of signals came into view in 1H NMR of THZP8‐THZP14 exhibited the presence of a configurational isomeric mixture of 2E,5Z (38.24%‐41.58%) and 2Z,5Z isomers (58.42%‐61.76%), which was further endorsed by density functional theory (DFT) studies. All the compounds exhibit promising nonlinear optical properties (NLO). Further, the biological potential of THZPs was explored in terms of α‐amylase and α‐glucosidase inhibition. DFT‐based descriptors were calculated to describe the reactivity, and a relationship was developed with biological activities. THZP9 and THZP14 showed remarkable inhibition of α‐amylase and α‐glucosidase with IC50 9.90μM and 4.84μM, respectively, as compared with standard drug acarbose.

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010 Advanced glycation end products induce functional impairment in neonatal rat cardiomyocytes through enhanced production of reactive oxygen species

Cited by 2 publications

References 0 publications

Multiphoton imaging of the monosachharide induced formation of fluorescent advanced glycation end products in tissues

Multiphoton imaging of the monosachharide induced formation of fluorescent advanced glycation end products in tissues

Thiazolidine‐4‐one clubbed pyrazoles hybrids: Potent α‐amylase and α‐glucosidase inhibitors with NLO properties

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