0.3% Ciprofloxacin Ophthalmic Ointment in the Treatment of Bacterial Keratitis

Strategies for the management of microbial keratitis.

“…In a review of consecutive patients (n= 70) treated in this department in 1993/4 (unpublished data), using either ofloxacin orfortified combination treatment (cefuroxime and gentamicin) as intensive initial therapy, approximately two thirds ofpatients had healed at 1 week and over 90% had healed within 1 month (that is, after up to 3 weeks ofphase 2 therapy). data - Fig 4) compare well with those for contemporary studies in which high dose antibiotic treatment was gradually reduced.20 21 The majority of patients with microbial keratitis can be managed successfully as outpatients28 with initial review after 48 hours. Admission may be necessary where good compliance is unlikely (for example, elderly or debilitated patients with poor social support); or for overnight treatment in severe infections (axial lesions, lesions 6 mm or more in diameter, or with 50% or more stromal thinning) in which the margin for error in terms of undertreatment or poor compliance may be smaller.…”

Strategies for the management of microbial keratitis.

“…In a review of consecutive patients (n= 70) treated in this department in 1993/4 (unpublished data), using either ofloxacin orfortified combination treatment (cefuroxime and gentamicin) as intensive initial therapy, approximately two thirds ofpatients had healed at 1 week and over 90% had healed within 1 month (that is, after up to 3 weeks ofphase 2 therapy). data - Fig 4) compare well with those for contemporary studies in which high dose antibiotic treatment was gradually reduced.20 21 The majority of patients with microbial keratitis can be managed successfully as outpatients28 with initial review after 48 hours. Admission may be necessary where good compliance is unlikely (for example, elderly or debilitated patients with poor social support); or for overnight treatment in severe infections (axial lesions, lesions 6 mm or more in diameter, or with 50% or more stromal thinning) in which the margin for error in terms of undertreatment or poor compliance may be smaller.…”

Fluoroquinolone and fortified antibiotics for treating bacterial corneal ulcers

“…Similarly, Wilhelmus et al found that clinical success occurred in 93% of the patients treated with ciprofloxacin ointment used for a shorter mean duration than conventional agents 11. In this prospective study more patients in the non-enrolled group treated with conventional therapy experienced failure than in the ciprofloxacin group.…”

ProlongedCurvularia EndophthalmitisDue to Organism Sequestration

“…11 In the present traumarelated case of Curvularia endophthalmitis, the trauma was due to nail injury. No unusual exposure was seen in surgeryrelated cases.…”

Strategies for the management of microbial keratitis.

“…In a review of consecutive patients (n= 70) treated in this department in 1993/4 (unpublished data), using either ofloxacin orfortified combination treatment (cefuroxime and gentamicin) as intensive initial therapy, approximately two thirds ofpatients had healed at 1 week and over 90% had healed within 1 month (that is, after up to 3 weeks ofphase 2 therapy). data - Fig 4) compare well with those for contemporary studies in which high dose antibiotic treatment was gradually reduced.20 21 The majority of patients with microbial keratitis can be managed successfully as outpatients28 with initial review after 48 hours. Admission may be necessary where good compliance is unlikely (for example, elderly or debilitated patients with poor social support); or for overnight treatment in severe infections (axial lesions, lesions 6 mm or more in diameter, or with 50% or more stromal thinning) in which the margin for error in terms of undertreatment or poor compliance may be smaller.…”

Fluoroquinolone and fortified antibiotics for treating bacterial corneal ulcers

“…Similarly, Wilhelmus et al found that clinical success occurred in 93% of the patients treated with ciprofloxacin ointment used for a shorter mean duration than conventional agents 11. In this prospective study more patients in the non-enrolled group treated with conventional therapy experienced failure than in the ciprofloxacin group.…”

ProlongedCurvularia EndophthalmitisDue to Organism Sequestration

“…11 In the present traumarelated case of Curvularia endophthalmitis, the trauma was due to nail injury. No unusual exposure was seen in surgeryrelated cases.…”

Strategies for the management of microbial keratitis.

“…In a review of consecutive patients (n= 70) treated in this department in 1993/4 (unpublished data), using either ofloxacin orfortified combination treatment (cefuroxime and gentamicin) as intensive initial therapy, approximately two thirds ofpatients had healed at 1 week and over 90% had healed within 1 month (that is, after up to 3 weeks ofphase 2 therapy). data - Fig 4) compare well with those for contemporary studies in which high dose antibiotic treatment was gradually reduced.20 21 The majority of patients with microbial keratitis can be managed successfully as outpatients28 with initial review after 48 hours. Admission may be necessary where good compliance is unlikely (for example, elderly or debilitated patients with poor social support); or for overnight treatment in severe infections (axial lesions, lesions 6 mm or more in diameter, or with 50% or more stromal thinning) in which the margin for error in terms of undertreatment or poor compliance may be smaller.…”

Fluoroquinolone and fortified antibiotics for treating bacterial corneal ulcers

“…Similarly, Wilhelmus et al found that clinical success occurred in 93% of the patients treated with ciprofloxacin ointment used for a shorter mean duration than conventional agents 11. In this prospective study more patients in the non-enrolled group treated with conventional therapy experienced failure than in the ciprofloxacin group.…”

ProlongedCurvularia EndophthalmitisDue to Organism Sequestration

“…11 In the present traumarelated case of Curvularia endophthalmitis, the trauma was due to nail injury. No unusual exposure was seen in surgeryrelated cases.…”