β-Cyclodextrin: 52-Week toxicity studies in the rat and dog

Long-Term Parenteral Administration of 2-Hydroxypropyl-β-Cyclodextrin Causes Bone Loss

“…In a similar fashion, increased serum AST and ALP in HP-b-CD-treated rats were reported in earlier experiments (Gould et al 2005). Furthermore, hepatotoxicity of long-term dietary administration of b-CD has also been suggested by a previous study (Bellringer et al 1995). The authors observed increased centrilobular enlargement of hepatocytes which was interpreted as an adaptation response of the rodent liver to xenobiotics.…”

Long-Term Parenteral Administration of 2-Hydroxypropyl-β-Cyclodextrin Causes Bone Loss

“…In a similar fashion, increased serum AST and ALP in HP-b-CD-treated rats were reported in earlier experiments (Gould et al 2005). Furthermore, hepatotoxicity of long-term dietary administration of b-CD has also been suggested by a previous study (Bellringer et al 1995). The authors observed increased centrilobular enlargement of hepatocytes which was interpreted as an adaptation response of the rodent liver to xenobiotics.…”

Single- and 14-Day Repeat-Dose Toxicity of Cross-Linked β-Cyclodextrin in Rats

“…The main objective of this study was to investigate oral acute and repeat-dose toxicity of cross-linked β-CD by adipic acid in rats. The toxicity of β-CD was found in the earlier study conducted by Bellringer et al 21 before investigating the cross-linking. These studies included 52-week toxicity studies in rats and dogs, carcinogenicity studies in mice and rats, and a 3-generation reproductive toxicity study in rats with a teratology phase.…”

Subchronic (13-week) oral toxicity study of α-cyclodextrin in dogs

“…In particular, no microscopic changes were observed in the kidneys and liver, the two known target organs of b-cyclodextrin toxicity (Bellringer et al, 1995), nor in the cecum and colon which exhibited an increased weight in the 10 and 20% dose groups, nor in the stomach and duodenum which were directly exposed to the ingested a-CD (Table 4).…”

Long-Term Parenteral Administration of 2-Hydroxypropyl-β-Cyclodextrin Causes Bone Loss

“…In a similar fashion, increased serum AST and ALP in HP-b-CD-treated rats were reported in earlier experiments (Gould et al 2005). Furthermore, hepatotoxicity of long-term dietary administration of b-CD has also been suggested by a previous study (Bellringer et al 1995). The authors observed increased centrilobular enlargement of hepatocytes which was interpreted as an adaptation response of the rodent liver to xenobiotics.…”

Single- and 14-Day Repeat-Dose Toxicity of Cross-Linked β-Cyclodextrin in Rats

“…The main objective of this study was to investigate oral acute and repeat-dose toxicity of cross-linked β-CD by adipic acid in rats. The toxicity of β-CD was found in the earlier study conducted by Bellringer et al 21 before investigating the cross-linking. These studies included 52-week toxicity studies in rats and dogs, carcinogenicity studies in mice and rats, and a 3-generation reproductive toxicity study in rats with a teratology phase.…”

Subchronic (13-week) oral toxicity study of α-cyclodextrin in dogs

“…In particular, no microscopic changes were observed in the kidneys and liver, the two known target organs of b-cyclodextrin toxicity (Bellringer et al, 1995), nor in the cecum and colon which exhibited an increased weight in the 10 and 20% dose groups, nor in the stomach and duodenum which were directly exposed to the ingested a-CD (Table 4).…”

Long-Term Parenteral Administration of 2-Hydroxypropyl-β-Cyclodextrin Causes Bone Loss

“…In a similar fashion, increased serum AST and ALP in HP-b-CD-treated rats were reported in earlier experiments (Gould et al 2005). Furthermore, hepatotoxicity of long-term dietary administration of b-CD has also been suggested by a previous study (Bellringer et al 1995). The authors observed increased centrilobular enlargement of hepatocytes which was interpreted as an adaptation response of the rodent liver to xenobiotics.…”

Single- and 14-Day Repeat-Dose Toxicity of Cross-Linked β-Cyclodextrin in Rats

“…The main objective of this study was to investigate oral acute and repeat-dose toxicity of cross-linked β-CD by adipic acid in rats. The toxicity of β-CD was found in the earlier study conducted by Bellringer et al 21 before investigating the cross-linking. These studies included 52-week toxicity studies in rats and dogs, carcinogenicity studies in mice and rats, and a 3-generation reproductive toxicity study in rats with a teratology phase.…”

Subchronic (13-week) oral toxicity study of α-cyclodextrin in dogs

“…In particular, no microscopic changes were observed in the kidneys and liver, the two known target organs of b-cyclodextrin toxicity (Bellringer et al, 1995), nor in the cecum and colon which exhibited an increased weight in the 10 and 20% dose groups, nor in the stomach and duodenum which were directly exposed to the ingested a-CD (Table 4).…”